Author

T. G. Laughlin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 5 Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Organism:E. coli· 1 Assay:electronic health records· 1

Frequent Co-Authors

E. Villa· 5 shared J. Pogliano· 5 shared J. Lee· 4 shared K. D. Corbett· 4 shared E. A. Birkholz· 3 shared E. Armbruster· 3 shared K. Pogliano· 3 shared S. Suslov· 3 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

E. Villa

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A mobile intron facilitates interference competition between co-infecting viruses

E. A. Birkholz, C. J. Morgan, T. G. Laughlin, R. K. Lau, A. Prichard, S. Rangarajan, G. N. Meza, J. Lee, E. G. Armbruster, S. Suslov, K. Pogliano, J. R. Meyer, E. Villa, K. D. Corbett, J. Pogliano

The paper shows a mobile intron in bacteriophage ΦPA3 uses its homing endonuclease to interfere with co-infecting phage ΦKZ, providing a competitive reproductive advantage.

bioRxiv · Sep 30, 2023 · PreprintMicrobiology

A transcriptionally active lipid vesicle encloses theinjected Chimalliviridae genome in early infection

E. Armbruster, P. Rani, J. Lee, N. Klusch, J. Hutchings, L. Y. Hoffman, H. Buschkaemper, E. Enustun, B. Adler, K. Inlow, A. VanderWal, M. Y. Hoffman, D. Daksh, A. Aindow, A. Deep, , J. Pogliano

The paper shows that Chimalliviridae form a lipid membrane-bound EPI vesicle during early infection, which hosts transcription of the phage genome, and demonstrates the necessity of a second compartment, the phage nucleus, for genome replication.

bioRxiv · Sep 20, 2023 · PreprintCell Biology

Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY

A. Prichard, J. Lee, T. G. Laughlin, A. Lee, K. P. Thomas, A. Sy, T. Spencer, A. Asavavimol, A. Cafferata, M. Cameron, N. Chiu, D. Davydov, I. Desai, G. Diaz, M. Guereca, , J. Pogliano

The paper identifies a core genome of nucleus-forming bacteriophages and characterizes the replication mechanism of Erwinia phage RAY.

bioRxiv · Feb 24, 2023 · PreprintMicrobiology

Architecture and self-assembly of the jumbo bacteriophage nuclear shell

T. G. Laughlin, A. Deep, A. M. Prichard, C. Seitz, Y. Gu, E. Enustun, S. Suslov, K. Khanna, E. A. Birkholz, E. Armbruster, J. A. McCammon, R. E. Amaro, J. Pogliano, K. D. Corbett, E. Villa

The paper identifies chimallin as the primary protein forming the bacteriophage nuclear shell and characterizes its self-assembly into closed compartments.

bioRxiv · Feb 14, 2022Biophysics

Discovery of a carbonic anhydrase-Rubisco complex within the alpha-carboxysome

C. Blikstad, E. J. Dugan, T. G. Laughlin, J. B. Turnsek, M. D. Liu, S. R. Shoemaker, N. Vogiatzi, J. P. Remis, D. F. Savage

This study identifies the structural basis of carbonic anhydrase incorporation into carboxysomes by showing direct interaction with Rubisco via an N-terminal domain.

bioRxiv · Nov 5, 2021 · PreprintBiochemistry

A Cytoskeletal Vortex Drives Phage Nucleus Rotation During Jumbo Phage Replication inE. coli

E. A. Birkholz, T. G. Laughlin, S. Suslov, E. Armbruster, J. Lee, J. Wittmann, K. D. Corbett, E. Villa, J. Pogliano

The paper identifies a cytoskeletal vortex in E. coli jumbo phage Goslar that drives phage nucleus rotation, similar to eukaryotic structures.

bioRxiv · Oct 25, 2021Microbiology