Author

M. Uhlen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 6 Cell Biology· 4 Immunology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 11 Organism:human· 10 Approach:experimental assay· 9 Assay:proteomics· 7 Research Focus:differential expression· 5 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

A. Bendes· 4 shared F. Edfors· 4 shared L. Fagerberg· 4 shared T. Dodig-Crnkovic· 4 shared J. M. Schwenk· 3 shared J. Schwenk· 3 shared A. Gummesson· 2 shared C. Fredolini· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

A. Bendes

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

Longitudinal Exposomics in a Multiomic Wellness Cohort Reveals Distinctive and Dynamic Environmental Chemical Mixtures in Blood

K. Sdougkou, S. Papazian, B. Bonnefille, H. Xie, F. Edfors, L. Fagerberg, M. Uhlen, G. Bergström, L. J. Martin, J. W. Martin

This study applies longitudinal exposomics to a multiomic cohort, revealing dynamic environmental chemical mixtures and their associations with biological markers over time.

bioRxiv · Apr 14, 2024Pharmacology & Toxicology

Expanding the GPCR-RAMP interactome

I. B. Kotliar, A. Bendes, L. Dahl, Y. Chen, M. Saarinen, E. Ceraudo, T. Dodig, M. Uhlen, P. Svenningsson, J. Schwenk, T. Sakmar

The paper identifies 122 GPCRs interacting with RAMPs using a DuET library and SBA assay, expanding the GPCR-RAMP interactome to inform therapeutic design.

bioRxiv · Nov 22, 2023Biochemistry

Pathogenic entero- and salivatypes harbour changes in microbiome virulence and antimicrobial resistance genes with increasing chronic liver disease severity

S. Lee, B. Arefaine, N. Begum, M. Stamouli, E. Witherden, M. Mohamad, A. Harzandi, A. Zamalloa, H. Cai, L. A. Edwards, R. Williams, S. Chokshi, A. Mardinoglu, G. Proctor, D. L. Shawcross, , V. C. Patel

The paper identifies changes in oral and gut microbiome virulence and antimicrobial resistance genes associated with increasing severity of chronic liver disease.

bioRxiv · Aug 6, 2023 · PreprintPhysiology

Multiplexed selectivity screening of anti-GPCR antibodies

L. Dahl, I. Kotliar, A. Bendes, T. Dodig-Crnkovic, S. Fromm, A. Elofsson, M. Uhlen, T. P. Sakmar, J. Schwenk

The paper screens 400 anti-GPCR antibodies for selectivity using a multiplexed immunoassay against 215 solubilized GPCRs, finding 61% are selective, 11% bind off-target, and 28% bind none.

bioRxiv · Nov 24, 2022Biochemistry

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

A. Chen, S. Liao, M. Cheng, K. Ma, L. Wu, Y. Lai, X. Qiu, J. Yang, W. Li, J. Xu, S. Hao, X. Wang, H. Lu, X. Chen, X. Liu, , J. Wang

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

Cell · May 1, 2022Peer-reviewedCell Biology

The protein expression profile of ACE2 in human tissues

F. Hikmet, L. Mear, A. Edvinsson, P. Micke, M. Uhlen, C. Lindskog

This study maps ACE2 protein expression across >150 human cell types, revealing tissue-specific patterns relevant to SARS-CoV-2 infection.

bioRxiv · Mar 31, 2020Cell Biology

Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling

T. Dodig-Crnkovic, M.-G. Hong, C. Engel Thomas, R. S. Häussler, A. Bendes, M. Dale, F. Edfors, B. Forsström, P. K. Magnusson, I. Schuppe-Koistinen, J. Odeberg, L. Fagerberg, A. Gummesson, G. Bergström, M. Uhlen, J. Schwenk

This study profiles longitudinal plasma proteomes from healthy individuals to identify individual-specific health signatures and their genetic associations.

bioRxiv · Mar 13, 2020Biochemistry

Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder

L. Stenstrom, D. Mahdessian, C. Gnann, A. J. Cesnik, W. Ouyang, M. Leonetti, M. Uhlen, S. Cuylen-Haering, P. Thul, E. Lundberg

The paper maps the human nucleolar proteome, identifies a new subcompartment, and shows intrinsic disorder levels are higher in nucleolar and mitotic proteins.

bioRxiv · Jan 30, 2020Cell Biology

Human immune system variation during one year

T. Lakshmikanth, S. A. Muhammad, A. Olin, Y. Chen, J. Mikes, L. Fagerberg, A. Gummesson, G. Bergstrom, M. Uhlen, P. Brodin

This study characterizes longitudinal immune system variation in 99 adults over one year, finding that variability is an individual feature linked to metabolic health markers.

bioRxiv · Jan 22, 2020 · PreprintImmunology

Multiplexed Analysis of the Secretin-like GPCR-RAMP Interactome

E. Lorenzen, T. Dodig-Crnkovic, I. B. Kotliar, E. Pin, E. Ceraudo, R. D. Vaughan, M. Uhlen, T. Huber, J. M. Schwenk, T. P. Sakmar

This study identifies GPCR-RAMP interactions using a suspension bead array assay, revealing widespread interactions among secretin-like GPCRs and RAMPs.

bioRxiv · Apr 6, 2019Biochemistry

A systems-based map of human brain cell-type enriched genes and malignancy-associated endothelial changes

P. Dusart, B. M. Hallstrom, T. Renne, J. Odeberg, M. Uhlen, L. Butler

The paper identifies brain cell-type enriched genes and endothelial changes in malignancy using bulk RNAseq data from normal and glioma samples.

bioRxiv · Feb 5, 2019Cell Biology

Systematic Development Of Sandwich Immunoassays For The Plasma Secretome

R. S. Haeussler, A. Bendes, M. Iglesias, L. Sanchez-Rivera, T. Dodig-Crnkovic, S. Bystrom, C. Fredolini, E. Birgersson, M. Dale, F. Edfors, L. Fagerberg, J. Rockberg, H. Tegel, M. Uhlen, U. Qundos, J. M. Schwenk

The paper develops a workflow to build dual binder sandwich immunoassays for plasma secretome proteins, validating 102 targets and comparing assay performance with other methods.

bioRxiv · Jan 8, 2019Biochemistry

Screening a Resource of Recombinant Protein Fragments for Targeted Proteomics

F. Edfors, B. Forsstrom, H. Vunk, D. Kotol, C. Fredolini, G. Maddalo, A.-S. Svensson, T. Bostrom, H. Tegel, P. Nilsson, J. M. Schwenk, M. Uhlen

The paper screens a resource of recombinant protein fragments to identify proteotypic peptides for targeted proteomics and demonstrates their utility in quantifying proteins in human plasma.

bioRxiv · Nov 19, 2018Biochemistry