J. H. Shin

The paper examines the lifespan trajectory of striatal dopamine availability in primates and rodents, finding a delayed peak in adulthood and age-dependent modulation by GABA and acetylcholine.

The paper identifies differential expression of tension-sensitive HOX genes in fibroblasts across scar types and links it to tensional homeostasis in wound healing.

This paper uses high-throughput thermodynamic measurements to analyze the energetic architecture of an RNA tertiary motif, revealing non-linear cooperativity and exceptions to established stability-abundance relationships.

The paper shows that fingering patterns in epithelial layers influence gap closure speed through curvature-mediated forces, with fingering frequency inversely related to boundary curvature.

This study investigates how fluid shear stress affects microglia morphology and activation, finding that shear flow promotes a shift toward pro-inflammatory states.

This paper introduces RI-TFM, a high-speed label-free technique for 3D cellular mechanics, and demonstrates its ability to measure traction forces and morphology in cells.

The paper identifies a transcriptional signature in primary ccRCC tumors that predicts metastatic potential and patient survival.

This study reveals that vimentin intermediate filaments and F-actin form an interpenetrating network in the cell cortex, enhancing contractile forces and influencing actin dynamics.

This study demonstrates that prime editing can correct disease-causing mutations in adult mouse liver and retina, with minimal off-target effects.

This study shows that electrical stimulation after traumatic brain injury in rats promotes pro-healing microglia phenotypes, increases neural stem cells and Nestin+ astrocytes, and enhances neuronal viability.

This study shows fibroblasts can close large artificial wounds using a purse-string mechanism similar to epithelial cells, relying on myosin II and adherent junctions.

This paper develops a high-resolution microscopy method to image FDG in tumor organoids, mirroring clinical PET scans and predicting treatment response.

This study shows that intestinal FGF15 protects against muscle and bone loss after sleeve gastrectomy in mice.

This study investigates whether reduced branched-chain amino acid (BCAA) levels after vertical sleeve gastrectomy (VSG) contribute to metabolic improvements in mice, finding that BCAA reduction is not necessary for weight loss or glucose tolerance.

This paper demonstrates the feasibility of using PET imaging to track 89Zr-DFO-labeled CAR T-cells in vivo, showing their distribution and migration over time.

The paper analyzes DNA methylation in glioblastoma survivors to identify distinct methylation patterns linked to oncogenic pathways and mutation rates.

This study identifies an NSD1-inactivated, DNA hypomethylated, immune cold subtype in lung and head and neck squamous cell carcinomas, linked to poor immune infiltration and potential immunotherapy resistance.