K. Baek

High-throughput Microfluidic 3D Outer Blood-Retinal Barrier Model in a 96-Well Format: Analysis of Cellular Interactions and Barrier Function in Retinal Health and Disease

A High-Throughput Microphysiological Liver Chip System to Model Direct and Idiosyncratic Drug-Induced Liver Injury Using Human Liver Organoids

This paper introduces a high-throughput microfluidic liver chip system using human liver organoids to model drug-induced liver injury with improved sensitivity and prolonged drug exposure capabilities.

Insights into the ISG15 transfer cascade by the UBE1L activating enzyme

This study presents a cryo-EM structure of the UBE1L-UBE2L6 complex bound to ISG15, revealing mechanisms of ISG15 recognition and conjugation pathway specificity.

Analysis of spike protein variants evolved in a novel mouse model of persistent SARS-CoV-2 infection

The paper establishes a novel mouse model of persistent SARS-CoV-2 infection using Calu-3 xenografts and identifies spike protein mutations that enhance viral replication and host adaptation.

Activity-based profiling of cullin-RING ligase networks by conformation-specific probes

The paper develops conformation-specific probes to profile activated cullin-RING ligase networks, revealing differential regulation across cell types and activation pathways.