T. Ishii

Distinct adrenal gland macrophages regulate corticosteroid production

This study identifies two distinct adrenal macrophage subsets in mice and shows that foamy macrophages regulate corticosteroid production through cholesterol accumulation.

Plasticity in centromere organization: Holocentromeres can consist of merely a few megabase-sized satellite arrays

The paper analyzes the holocentromere organization in Chionographis japonica, revealing that its holocentromeres consist of few, large satellite arrays and differ from other holocentric species.

Hepatocyte Differentiation From Mouse Liver Ductal Organoids By Transducing Four Liver-Specific Transcription Factors

This study identifies four transcription factors that enhance hepatocyte differentiation from liver ductal organoids, improving their functionality and reducing cholangiocyte characteristics.

A stepwise route to domesticate rice by controlling seed shattering and panicle shape

This study identifies multiple genetic mutations required for rice domestication, showing that seed shattering loss alone is insufficient and that panicle shape plays a critical role in yield increase.

Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts

The paper demonstrates that liver ductal organoids can reconstruct intrahepatic bile ducts in decellularized liver grafts, mimicking native liver structure and function.

Interspecific introgression and natural selection in the evolution of Japanese apricot (Prunus mume)

The paper analyzes genome-wide SNPs in Prunus species to identify interspecific introgression and natural selection in Japanese apricot evolution.

High-throughput screening of high protein producer budding yeast using gel microdrop technology

This paper presents a high-throughput screening method using gel microdrop technology to isolate high protein producer budding yeast clones, improving protein production by five-fold.

Estrogen induces mammary ductal dysplasia.

This study shows estrogen can cause mammary ductal dysplasia in a mouse model and demonstrates that isoflavones can inhibit this effect.