Author

T. Isobe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

K. MIYAKE· 3 shared M. Taoka· 3 shared R. Fukui· 3 shared R. Sato· 3 shared T. Shibata· 3 shared Y. Motoi· 3 shared Y. Yamauchi· 3 shared E. Fujita· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

K. MIYAKE

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5Lhi hepatic macrophages

R. Sato, K. Liu, T. Shibata, K. Hoshino, K. Yamaguchi, T. Miyazaki, R. Hiranuma, R. Fukui, Y. Motoi, Y. Fukuda-Ohta, Y. Zhang, T. Reuter, Y. Ishida, T. Kondo, T. Chiba, , K. MIYAKE

The paper shows that microbiome ssRNA activates TLR13 in hepatic macrophages to drive tissue-protective responses, leading to resistance against acute liver injury in Rnaset2-/- mice.

bioRxiv · May 11, 2023 · PreprintImmunology

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

K. Miyake, T. Shibata, R. Sato, M. Taoka, S.-I. Saitoh, M. Komine, K. Yamaguchi, S. Goyama, Y. Motoi, J. Kitaura, K. Izawa, Y. Yamauchi, Y. Tsukamoto, T. Ichinohe, E. Fujita, , T. Taguchi

This study identifies TLR7/8 as drivers of histiocytosis in SLC29A3 disorders by responding to lysosomal nucleoside stress and enhancing monocyte proliferation and phagocyte maturation.

bioRxiv · Oct 27, 2022Immunology

Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR7

T. Shibata, M. Taoka, S.-I. Saitoh, Y. Yamauchi, Y. Motoi, M. Komine, E. Fujita, R. Sato, H. Sagara, T. Ichinohe, M. Kawazoe, C. Kato, K. Furusho, Y. Murakami, R. Fukui, , K. MIYAKE

This study shows that TLR7 activation by accumulated nucleosides in lysosomes drives histiocytosis in SLC29A3 disorders.

bioRxiv · Dec 16, 2019 · PreprintImmunology

Estrogenic action by tris(2,6-dimethylphenyl) phosphate, an impurity in resorcinol bis flame retardant formulations, impairs the development of female reproductive functions

K. Sano, H. Matsukami, G. Suzuki, N. T. T. Htike, M. Morishita, T. T. Win Shwe, S. Hashimoto, T. Kawashima, T. Isobe, S. F. Nakayama, S. Tsukahara, F. Maekawa

This study shows that TDMPP, an estrogenic flame retardant impurity, affects female reproductive functions by altering brain development in mice.

bioRxiv · Feb 4, 2019 · PreprintPharmacology & Toxicology