T. Chiba

Dicarboxylic acid supplementation protects from acute kidney injury via stimulation of renal peroxisomal activity

This study shows that DC8 supplementation reduces AKI markers and promotes peroxisomal FAO over mitochondrial FAO in mice with kidney injury.

Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5Lhi hepatic macrophages

The paper shows that microbiome ssRNA activates TLR13 in hepatic macrophages to drive tissue-protective responses, leading to resistance against acute liver injury in Rnaset2-/- mice.

ECPAS/Ecm29-Mediated 26S Proteasome Disassembly Is an Adaptive Response to Glucose Starvation

This study shows that ECPAS-mediated 26S proteasome disassembly into 20S and 19S subcomplexes occurs during glucose starvation, enhancing proteolysis and cell survival.

Metformin preconditioning protects against myocardial stunning and preserves mitochondrial dynamics and protein translation in a mouse model of cardiac arrest

This study shows metformin pretreatment protects against cardiac and renal damage after cardiac arrest in mice through AMPK activation, preserving protein translation and mitochondrial function.

A novel ultrasound-guided mouse model of sudden cardiac arrest

This paper develops an ultrasound-guided method to induce sudden cardiac arrest in mice, showing rapid asystole and reliable survival rates with secondary organ damage but no neurologic dysfunction.

Proteasome activator PA200 maintains stability of histone marks during transcription and aging

This study shows that PA200 maintains histone mark stability during transcription and aging by promoting acetylation-dependent degradation of core histones.

Morphogenesis of giant telomeric nuclear bodies in cancer cells with alternative lengthening of telomeres

The paper quantifies giant telomeric nuclear bodies (GT-NBs) in ALT cancer cells and shows they form by aggregating telomeres and associate with PML-NBs.