C. Fu

Phenotypic screens identify biologic regulators of nanoparticle uptake in diffuse midline glioma

The paper identifies biologic regulators of nanoparticle uptake in diffuse midline glioma using CRISPR screens and functional assays, finding CTNNB1 and pathway members as key modulators.

Cancer vaccine attenuates carcinogen induced head and neck cancer with impaired early T cell response

This study shows that a cancer vaccine combined with anti-PD-1 therapy reduces tumor burden and improves survival in a head and neck cancer model with impaired T cell responses.

Targeting GFPT2 to reinvigorate immunotherapy in EGFR-mutated NSCLC

This study identifies GFPT2 as a metabolic checkpoint in EGFR-mutated NSCLC that promotes immune evasion, and shows that targeting GFPT2 enhances PD-1 blockade therapy.

In vitro antimicrobial mechanism of diacerein and potential to reverse MRSE resistance to β-lactams

This study investigates diacerein's antimicrobial mechanism against MRSE and shows it can reverse β-lactam resistance by affecting efflux systems and inducing cell lysis.

E-cadherin-dependent phosphorylation of EGFR governs a homeostatic feedback loop controlling intercellular junction viscosity and collective migration modes.

Cortical ductility governs cell-cell adhesion mechanics

This study introduces a new method to measure energy dissipation during cell-cell junction rupture and shows that cortical tension and shape relaxation time determine whether junctions behave ductile or brittle.

Kin selection underpins family dynamics in rural China

The study uses an evolutionary game model and rural Chinese family data to show that kin selection influences family size by adjusting co-resident members to maintain relatedness and inclusive fitness.

A KDELR-mediated ER retrieval system guides the signaling pathways of UPR and AMPK to maintain cellular homeostasis

This study shows that the KDELR/Erd2-mediated ER retrieval system regulates UPR and AMPK signaling to maintain cellular homeostasis by affecting mitochondrial respiration and ROS levels.

Step-wise mechanical unfolding and dissociation of the GAIN domains of ADGRG1/GPR56, ADGRL1/Latrophilin-1 and ADGRB3/BAI3: insights into the mechanical activation hypothesis of adhesion G protein-coupled receptors

This study examines how mechanical forces affect the GAIN domains of three aGPCRs, showing force-induced destabilization and detachment, supporting the mechanical activation hypothesis.

Proliferating cell nuclear antigen involves in temperature stress tolerance of Ulva prolifera

This study identifies PCNA's role in temperature stress tolerance of Ulva prolifera, showing its interaction with CyclinA and regulation by miR-2916 through the MAPK pathway.

Crystal structure of a mammalian CMTM6 and its interaction model with PD-L1

The paper reports the first experimentally determined structure of CMTM6 and proposes an interaction model with PD-L1, providing structural insights into its role in stabilizing the PD-1/PD-L1 axis.

Cell dichotomous role of STING in pulmonary hypertension

This study investigates the role of STING in pulmonary hypertension, finding that STING overactivation contributes to disease while global deficiency protects against it, with distinct cellular roles in smooth muscle and myeloid cells.

Insights into the biosynthesis of icumazole unveiling a distinctive family of crotonyl-CoA carboxylase/reductase

The paper identifies a novel family of crotonyl-CoA carboxylase/reductase (CCR) enzymes involved in icumazole biosynthesis, revealing unique substrate specificity and cofactor usage.

Wnt7a Suppresses Adipogenesis of Skeletal Muscle Mesenchymal Stem Cells and Fatty Infiltration Through the Alternative Wnt-Rho-YAP/TAZ Signaling Axis

This study shows Wnt7a inhibits adipogenesis of fibro-adipogenic progenitors and reduces fatty infiltration in muscle through the Wnt-Rho-YAP/TAZ signaling pathway.

Cryo-EM structure of a eukaryotic zinc transporter at a low pH suggests its Zn2+-releasing mechanism

The paper presents a cryo-EM structure of ZnT8 at low pH, suggesting protons disrupt Zn2+ coordination, aiding its release into the lumen.

DINAVID: A Distributed and Networked Image Analysis System for Volumetric Image Data

DINAVID provides a cloud-based system for remote 3D microscopy image analysis and visualization, designed to handle large datasets and improve accessibility.

Novel ERR pan-agonists ameliorate heart failure through boosting cardiac fatty acid metabolism and mitochondrial function

This study develops two ERR agonists that improve heart failure by enhancing fatty acid metabolism and mitochondrial function in mice.

Macrophage proliferation machinery leads to PDAC progression, but susceptibility to innate immunotherapy.

This study shows that TAM proliferation in PDAC is driven by CSF1 from fibroblasts, leading to immunosuppression and tumor progression, but also increasing sensitivity to CD40 agonist therapy.

Scrutiny of human lung infection by SARS-CoV-2 and associated human immune responses in humanized mice

This study shows that humanized mice can be infected by SARS-CoV-2, leading to immune responses and immunopathology, providing a model for studying the virus and testing therapies.

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

This study shows that Cystathionine-β-synthase (CBS) maintains AKT-induced senescence and suppresses gastric cancer growth in PI3K/AKT-activated cells.

Acquisition of cancer stem cell properties during EMT requires cell division

This study shows that cancer cells acquire stem cell properties during EMT through cell division, not the mesenchymal program, and highlights the importance of EMT-induced stemness markers for clinical prediction.

Dynamic genome plasticity during unisexual reproduction in the human fungal pathogen Cryptococcus deneoformans

This study identifies cell cycle regulators involved in ploidy transitions during unisexual reproduction in C. deneoformans and reveals segmental aneuploidy associated with azole resistance.

Cooperative regulation of adherens junction elongation through Epidermal Growth Factor Receptor (EGFR) activation.

The paper shows that EGFR activation increases adherens junction elongation speed without affecting final size in suspended cell aggregates.

The Cdc42 GTPase activating protein Rga6 promotes the cortical localization of Septin

This study identifies Rga6 as a protein that promotes Septin complex localization to the cell cortex in fission yeast, supporting a model of polarized cell growth regulation.

Horizontal gene transfer in the human and skin commensal Malassezia: a bacterially-derived flavohemoglobin is required for NO resistance and host interaction

This study identifies bacterially-derived flavohemoglobin in Malassezia, acquired via horizontal gene transfer, as essential for nitric oxide resistance and host interaction.

Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I

This study compares spindle dynamics in mitosis and meiosis I using fission yeast, showing Klp2 maintains meiotic spindle stability with Ase1, but not mitotic spindles.

Unisexual reproduction promotes competition for mating partners in the global human fungal pathogen Cryptococcus deneoformans

This study shows unisexual reproduction in Cryptococcus deneoformans enhances mating competition by promoting hyphal growth and pheromone response, despite a fitness cost.

Widespread arginine phosphorylation in human cells - a novel protein PTM revealed by mass spectrometry

This study identifies widespread arginine phosphorylation in human cells using a novel phosphoproteomic workflow, revealing 152 high-confidence sites across 118 proteins.

Mitochondrial cristae biogenesis coordinates with ETC complex IV assembly during Drosophila maturation