T. Olender

Loss of EIF4G2 Mediates Aggressiveness in Distinct Human Endometrial Cancer Subpopulations with Poorer Survival Outcome in Patients

This study shows that low EIF4G2 expression in Grade 2 endometrial cancer correlates with poor survival and drug resistance, suggesting it as a potential biomarker.

Sedentary behavior may accelerate aging through impact on epigenome and transcriptome: lessons from muscle inactivation in Drosophila larvae

This study shows that muscle inactivation in Drosophila larvae alters chromatin epigenetic balance and downregulates genes related to longevity and metabolism.

Metabolic rewiring of the probiotic bacterium Lacticaseibacillus rhamnosus GG contributes to cell wall remodeling and antimicrobials production

This study shows that fermentation in LGG alters its metabolome, proteome, and cell wall properties, enhancing antimicrobial activity against pathogens.

Arabidopsis thaliana induces multigenerational stress tolerance against biotic and abiotic stressors and memorization of host colonization in Bacillus subtilis

This study shows that Arabidopsis thaliana secretions induce multigenerational stress tolerance in Bacillus subtilis, enhancing its colonization and resistance to stressors.

LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

This study shows LIS1 regulates mESCs viability and mechanosensitive properties through RNA-binding interactions with AGO2 and other proteins.

The LINC complex inhibits excessive chromatin repression

The paper shows that the LINC complex prevents excessive chromatin repression by restricting repressive H3K27me3 clusters and maintaining RNA-Pol II binding to muscle genes.

Global analysis of human-to-mouse contact-dependent intercellular mRNA and lncRNA transfer in cell culture

The paper quantifies mRNA and lncRNA transfer between human and mouse cells in co-culture, showing non-selective transfer and correlation with donor gene expression.

The Serine Protease HtrA2 mediates radiation-induced senescence in cancer cells

This study identifies HtrA2 as a mediator of radiation-induced senescence in cancer cells, showing its role in proliferation arrest and vimentin filament reorganization.

SMPD3 suppresses IDH mutant tumor growth via dual autocrine-paracrine roles

This study shows SMPD3 suppresses IDH mutant glioma growth through autocrine and paracrine mechanisms, with higher SMPD3 linked to longer survival in patients.

The formation of microbial exoskeletons is driven by a controlled calcium-concentrating subcellular niche

This paper identifies a calcium-accumulating subcellular niche in bacteria that drives biofilm mineralization, showing its conservation across species and potential as a drug target.

Identification of a secretion-enhancing cis regulatory targeting element (SECReTE) involved in mRNA localization and protein synthesis

The paper identifies SECReTE, a cis regulatory element in mRNAs that enhances secretion and localization to the nuclear ER in yeast by increasing protein synthesis and secretion.