G. Bajpai

Affinity hierarchies and amphiphilic proteins underlie the co-assembly of nucleolar and heterochromatin condensates

This study identifies an amphiphilic protein, Pitchoune, that mediates interactions between nucleoli and pericentromeric heterochromatin condensates during Drosophila development.

Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis

This study identifies an inflammatory macrophage population expanded in ICI myocarditis, driven by IFN-γ signaling and T-cell interactions, suggesting IFN-γ blockade as a potential therapeutic strategy.

Regulation of chromatin microphase separation by adsorbed protein complexes

The paper models chromatin organization as a multiblock copolymer and shows that protein binding regulates its microphase separation.

Polymer dynamics relates chromosome mixing to temporal changes in biological contact maps

The paper quantifies chromosome mixing dynamics using a polymer simulation, showing a power-law increase in mixing index over time with varying scaling exponents based on self-interaction and volume fraction.

The LINC complex inhibits excessive chromatin repression

The paper shows that the LINC complex prevents excessive chromatin repression by restricting repressive H3K27me3 clusters and maintaining RNA-Pol II binding to muscle genes.

Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

Mesoscale phase separation of chromatin in the nucleus

The paper uses intact-organism imaging of Drosophila larvae to show chromatin phase separation and demonstrates a polymeric model explains the observed nuclear organization transitions.

Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes

The paper analyzes metabolic diversity in mononuclear phagocytes across tissues using integrated datasets and a network-based approach, identifying key metabolic subnetworks and their functional roles.

Live imaging of chromatin distribution in muscle nuclei reveals novel principles of nuclear architecture and chromatin compartmentalization

The paper uses live imaging to show that chromatin forms a peripheral layer in Drosophila muscle nuclei, revealing a new model of nuclear architecture and chromatin compartmentalization.

Irregular chromatin: packing density, fiber width and occurrence of heterogeneous clusters

The paper investigates how chromatin is folded at the gene scale, showing that non-histone proteins contribute to irregular packing without altering fiber width or density.