Author

U. Protzer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Assay:metagenomics· 2 Organism:mouse· 2

Frequent Co-Authors

D. Haller· 2 shared D. Schult· 2 shared F. Momburg· 2 shared J. A. McKeating· 2 shared K. Neuhaus· 2 shared K. Steiger· 2 shared K.-P. Janssen· 2 shared M. Quante· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

D. Haller

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Hepatitis B virus neutralization with DNA origami nanoshells

E.-M. Willner, F. Kolbe, F. Momburg, U. Protzer, H. Dietz

This study uses DNA origami nanoshells to neutralize hepatitis B virus in cell culture by trapping the virus and enhancing antibody effectiveness through multivalent binding and physical barriers.

bioRxiv · Dec 20, 2023Biophysics

Gut microbial disruption in critically ill patients with COVID-19 associated pulmonary aspergillosis

D. Schult, C. Maurer, P. Koyumdzhieva, S. Reitmeier, M. Middelhoff, S. Rasch, M. List, K.-P. Janssen, K. Steiger, U. Protzer, R. M. Schmid, K. Neuhaus, D. Haller, M. Quante, T. Lahmer

This study investigates the gut and bronchial microbiota in critically ill COVID-19 patients with and without CAPA, finding reduced gut diversity and increased Staphylococcus epidermidis in CAPA patients.

bioRxiv · Oct 8, 2022Microbiology

Gut Bacterial Dysbiosis and Instability is Associated with the Onset of Complications and Mortality in COVID-19

D. Schult, S. Reitmeier, P. Koyumdzhieva, M. Middelhof, J. Erber, J. Schneider, J. Krager, M. Frolova, J. Horstmann, L. Fricke, K. Steiger, M. Jesinghaus, K.-P. Janssen, U. Protzer, K. Neuhaus, , M. Quante

The paper analyzes gut and oral microbiota in COVID-19 patients to show associations between microbial dysbiosis, complications, and mortality.

bioRxiv · Oct 8, 2021Microbiology

Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane

L. Zhao, F. Chen, O. Quitt, M. Festag, M. Ringelhan, K. Wisskirchen, J. Hasreiter, L. Yakovleva, C. Sureau, F. Bohne, M. Aichler, V. Bruss, M. Shevtsov, M. A. van de Klundert, F. Momburg, , U. Protzer

This study shows HBV envelope proteins are present on the host cell plasma membrane and can be targeted by T-cells for therapeutic purposes.

bioRxiv · Dec 21, 2020Microbiology

Efficient inhibition of SARS-CoV-2 strains by a novel ACE2-IgG4-Fc fusion protein with a stabilized hinge region

H. L. Svilenov, J. Sacherl, A. Reiter, L. Wolff, C.-C. Chen, M. Stern, F.-P. Wachs, N. Simonavicius, S. Pippig, F. Wolschin, J. Buchner, C. Brockmeyer, U. Protzer

This paper describes a novel ACE2-IgG4-Fc fusion protein that inhibits SARS-CoV-2 strains efficiently with improved pharmaceutical properties and broad antiviral activity.

bioRxiv · Dec 6, 2020 · PreprintImmunology

Synchronized infection identifies early rate-limiting steps in the hepatitis B virus life cycle.

A. Chakraborty, C. Ko, C. Henning, A. Lucko, X. Zhuang, J. M. Wettengel, U. Protzer, J. A. McKeating

This study uses synchronized infection to analyze HBV entry and cccDNA formation, finding that most viral particles enter cells but only a small fraction becomes cccDNA, highlighting a rate-limiting step in infection.

bioRxiv · Apr 5, 2020Microbiology

Hypoxic gene expression in chronic hepatitis B infected patients is not observed in state-of-art in vitro and mouse infection models

P. J. Liu, J. M. Harris, E. Marchi, V. D'Arienzo, T. Michler, P. A. Wing, A. Magri, A. Otega-Prieto, M. Van de Klundert, J. Wettengel, D. Durantel, M. Dorner, P. Klenerman, U. Protzer, S. Giotis, J. A. McKeating

The paper shows hypoxia gene upregulation in chronic hepatitis B patients is not observed in in vitro or mouse models, suggesting inflammatory factors may drive this effect.

bioRxiv · Mar 27, 2020Microbiology