Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes
N. Nagy, G. Kaber, V. Sunkari, P. L. Marshall, A. Hargil, H. F. Kuipers, H. Ishak, M. Bogdani, R. Hull, M. Grandoch, J. Fischer, T. McLaughlin, T. Wight, P. Bollyky
This study shows that inhibiting hyaluronan synthesis with 4-MU prevents β-cell loss in obesity-associated type 2 diabetes by increasing survivin expression and blocking apoptosis.
bioRxiv · Feb 28, 2023Immunology