Author

T. Dharmaraj

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Biophysics· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:software / tool· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

A. Hargil· 3 shared F. G. Blankenberg· 3 shared P. L. Bollyky· 3 shared Q. Chen· 3 shared A. Echterhof· 2 shared J. D. Berry· 2 shared J. D. Van Belleghem· 2 shared M. Hajfathalian· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersBioengineering

A. Hargil

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The contribution of neutrophils to bacteriophage clearance and pharmacokinetics in vivo

A. Echterhof, T. Dharmaraj, R. McBride, J. D. Berry, M. Hopkins, H. Selvakumar, K.-Y. Lin, L. Chia, C.-C. Shen, W. Lioa, P. Lee, T. Yeh, G. Suh, F. G. Blankenberg, A. Frymoyer, P. Bollyky

This study examines how neutrophils affect bacteriophage clearance and pharmacokinetics in mice, finding minimal impact from neutrophils but significant inactivation of phages over time.

JCI Insight · Oct 22, 2024Peer-reviewedPharmacology & Toxicology

Dosing and Delivery of Bacteriophage Therapy In a Murine Wound Infection Model

Y.-H. Lin, T. Dharmaraj, Q. Chen, A. Echterhof, R. Manasherob, L. J. Zhang, Z. Li, C. de Leeuw, N. A. Peterson, T. H. W. Chang, W. Stannard, M. Hajfathalian, A. Hargil, H. A. Martinez, J. Pourtois, , P. L. Bollyky

This study evaluates phage therapy dosing and delivery in a mouse wound infection model, finding topical high-dose repeated administration effective and developing a sustained-release hydrogel system.

bioRxiv · May 7, 2024Bioengineering

Rapid assessment of changes in phage bioactivity using dynamic light scattering

T. Dharmaraj, M. J. Kratochvil, J. D. Pourtois, Q. Chen, M. Hajfathalian, A. Hargil, Y.-H. Lin, Z. R. Evans, A. Oromi-Bosch, J. D. Berry, R. McBride, N. L. Haddock, D. R. Holman, J. D. Van Belleghem, T. H. Chang, , P. L. Bollyky

This paper uses Dynamic Light Scattering to assess phage bioactivity changes over time and optimize storage conditions for clinical phage applications.

bioRxiv · Jul 2, 2023Biophysics

Filamentous Bacteriophage Delay Healing of Pseudomonas-Infected Wounds

M. S. Bach, C. R. de Vries, A. Khosravi, J. M. Sweere, M. Popescu, A. Hargil, J. D. Van Belleghem, G. Kaber, Q. Chen, E. B. Burgener, D. Liu, Q.-L. Tran, T. Dharmaraj, M. Birukova, V. Sunkari, , P. L. Bollyky

This study shows filamentous bacteriophage delays wound healing in Pseudomonas aeruginosa infections by inhibiting keratinocyte migration, supported by a patient cohort study.

bioRxiv · Mar 10, 2020Microbiology

OGT (O-GlcNAc Transferase) selectively modifies multiple residues unique to lamin A

D. N. Simon, A. Wriston, Q. Fan, J. Shabanowitz, A. Florwick, T. Dharmaraj, S. B. Peterson, Y. Gruenbaum, C. R. Carlson, L. M. Gronning-Wang, D. F. Hunt, K. L. Wilson

This study identifies O-GlcNAc modifications unique to lamin A, showing OGT modifies specific residues in lamin A tails but not lamin B1, lamin C, or progerin.

bioRxiv · Oct 26, 2017Biochemistry