J. Fischer

Endoplasmic reticulum stress signaling actively contributes to therapy resistance in colorectal cancer

This study investigates how ER stress signaling contributes to therapy resistance in colorectal cancer by analyzing genomic alterations and testing therapeutic responses in cell lines and organoids.

ADEVO: Proof-of-concept of Adenovirus Directed EVOlution by random peptide display on the fiber knob

ADEVO demonstrates a method to generate high-complexity adenovirus libraries for retargeting, showing improved replication and lysis in tumor cells.

Overcoming Pitfalls when Estimating Variation in Parental Care: A Simulation Study

This paper demonstrates that failing to correct for offspring age in parental care analyses leads to overestimation of parental variation, and proposes a modeling approach to address this issue.

Gene regulatory Networks Reveal Sex Difference in Lung Adenocarcinoma

The paper identifies sex differences in gene regulatory networks in lung adenocarcinoma and identifies potential sex-biased cancer therapeutics.

(De)composing sociality: disentangling individual-specific from dyad-specific propensities to interact

This paper introduces a statistical framework to decompose social interactions into individual and dyadic components, using simulated and empirical data to demonstrate its application.

Fully Automated Sequential Immunofluorescence (seqIF) for Hyperplex Spatial Proteomics

The paper introduces seqIF, a fully automated method for hyperplex spatial proteomics, demonstrating its ability to analyze up to 40 proteins on a single tissue section in under 24 hours.

Alarm barks of male vervet monkeys as displays of male quality

The paper investigates whether male vervet monkey alarm barks serve to signal male quality in addition to alerting others to danger.

Genome-wide coancestry reveals details of ancient and recent male-driven reticulation in baboons

Genomic data from 225 baboons reveal novel inter-species gene flow sites and local admixture effects across different lineages.

Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes

This study shows that inhibiting hyaluronan synthesis with 4-MU prevents β-cell loss in obesity-associated type 2 diabetes by increasing survivin expression and blocking apoptosis.

Mitochondrial translocation of TFEB regulates complex I and inflammation

This study shows TFEB regulates mitochondrial complex I and inflammation through non-transcriptional mechanisms, with implications for immune pathogenesis during infection.

Deficiency in hyaluronan synthase 3 attenuates ruptures in a murine model of abdominal aortic aneurysms by reduced aortic monocyte infiltration

This study shows that deficiency in HAS3 reduces aortic ruptures in a murine AAA model by decreasing monocyte infiltration and ECM degradation.

Anti-integrin αvβ6 autoantibodies are a novel predictive biomarker in ulcerative colitis

This study identifies anti-integrin αvβ6 autoantibodies as a predictive biomarker for ulcerative colitis, showing they precede diagnosis by up to 10 years and correlate with adverse outcomes.

Male Guinea baboons are oblivious to their females' whereabouts

The study finds male Guinea baboons do not track the movement of their associated females, despite recognizing their voices.

MALE-MALE SOCIAL BONDING, COALITIONARY SUPPORT AND REPRODUCTIVE SUCCESS IN WILD GUINEA BABOONS

The paper examines the relationship between male-male bonding, coalitionary support, and reproductive success in wild Guinea baboons, finding that strong bonds do not enhance reproductive success, but reduced social investment correlates with higher reproductive output.

Extending Bayesian Elo-rating to quantify the steepness of dominance hierarchies

This paper introduces STEER, a Bayesian Elo-rating based method to estimate dominance hierarchy steepness, showing it is unbiased and more robust than existing metrics.

Hunting the plant surrender signal activating apoplexy in grapevines after Neofusicoccum parvum infection

The paper identifies trans-ferulic acid as a plant surrender signal that triggers fungal toxin production and programmed cell death in grapevines infected by Neofusicoccum parvum.

Kinetic Interval Measurement: A Tool to Characterize Thermal Reversion Dynamics of Light-switchable Fluorescent Proteins

The paper introduces KIM, a method to measure thermal reversion dynamics of light-switchable proteins using a microplate reader, showing its ability to determine reversion half-life and sensitivity to temperature and imidazole concentration.

S. Typhimurium impairs glycolysis-mediated acidification of phagosomes to evade macrophage defense

This study shows S. Typhimurium disrupts macrophage glycolysis to prevent phagosome acidification and evade immune defense.

A recombinant protein SARS-CoV-2 candidate vaccine elicits high-titer neutralizing antibodies in macaques.

This study evaluates a recombinant SARS-CoV-2 vaccine in macaques, showing that antigens from the RBD elicit high-titer neutralizing antibodies lasting over 20 weeks.

Vocal convergence in a multi-level primate society: insights into the evolution of vocal learning

The paper examines vocal convergence in Guinea baboons, finding that acoustic similarity in grunts correlates with social interactions rather than genetic relatedness, suggesting an implicit form of vocal learning.

Coordination during group departures and group progressions in the tolerant multilevel society of wild Guinea baboons (Papio papio)

This study examines group coordination in wild Guinea baboons, finding that both males and females initiate departures, and affiliated individuals tend to travel together.

Development of a monkey avatar to study social perception in macaques

The paper develops a virtual monkey avatar to study social perception in macaques and finds monkeys do not differentiate between real, realistic, or unrealistic images.

First report on the effective intraperitoneal therapy of insulin-dependent diabetes mellitus in pet dogs using \"Neo-Islets\", aggregates of adipose stem and pancreatic islet cells

This paper reports on the use of Neo-Islets in pet dogs to treat insulin-dependent diabetes, achieving improved glycemic control without immunosuppression or encapsulation.

Long-tailed macaques extract statistical information from repeated types of events to make rational decisions under uncertainty

This study shows long-tailed macaques use statistical information from repeated events to make rational decisions under uncertainty in complex scenarios.

Bayesian inference and simulation approaches improve the assessment of Elo-scores in the analysis of social behaviour

The paper compares Bayesian inference and maximum likelihood methods for Elo-scores in social behavior analysis, finding Bayesian methods more robust, especially with sparse data.