Author

J. Knox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:multiome· 1

Frequent Co-Authors

P. J. Roy· 2 shared A. Burns· 1 shared A. Devisme· 1 shared A. Dubuffet· 1 shared A. Macklin· 1 shared A. W. Reinke· 1 shared B. M. Murareanu· 1 shared B. T. Grünwald· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersPharmacology & Toxicology

P. J. Roy

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Author profile →

4 papers

Recent·Most cited

A Rapid in vivo Pipeline to Identify Small Molecule Inhibitors of Amyloid Aggregation

M. Kamal, J. Knox, R. I. Horne, O. S. Tiwari, A. Burns, D. Han, D. L. Bar-Yosef, E. Gazit, K. C. Nguyen, D. H. Hall, M. Vendruscolo, P. J. Roy

This paper presents an in vivo pipeline to identify small molecule inhibitors of amyloid aggregation by screening compounds that suppress crystal formation in C. elegans.

bioRxiv · Apr 11, 2022 · PreprintPharmacology & Toxicology

High-throughput small molecule screen identifies inhibitors of microsporidia invasion and proliferation in C. elegans.

B. M. Murareanu, N. V. Antao, W. Zhao, A. Dubuffet, H. El Alaoui, J. Knox, D. C. Ekiert, G. Bhabha, P. Roy, A. W. Reinke

This study screens FDA-approved compounds and natural products to identify inhibitors of microsporidia infection in C. elegans, finding five compounds that block spore firing and one that slows infection progression.

bioRxiv · Sep 6, 2021Microbiology

Spatially confined sub-tumor microenvironments orchestrate pancreatic cancer pathobiology

B. T. Grünwald, A. Devisme, G. Andrieux, F. Vyas, K. Aliar, C. W. McCloskey, A. Macklin, G. H. Jang, R. Denroche, J. M. Romero, P. Bavi, P. Bronsert, F. Notta, G. O'Kane, J. Wilson, , R. Khokha

This study identifies spatially confined sub-tumor microenvironments in PDAC that drive distinct tumor progression outcomes.

bioRxiv · Feb 18, 2021Cancer Biology

A Survey of the Kinome Pharmacopeia Reveals Multiple Scaffolds and Targets for the Development of Novel Anthelmintics

J. Knox, W. Zuercher, P. J. Roy

The paper identifies nematode-specific kinase targets and small molecule scaffolds for developing novel anthelmintics by screening vertebrate kinase inhibitors in C. elegans.

bioRxiv · Aug 20, 2020Pharmacology & Toxicology