Y. Abu-Amer

This study shows doxorubicin causes bone loss via inflammasome activation, leading to pyroptosis and NETosis, and identifies AIM2 and NLRP3 as key mediators.

This study shows that tenotomy-induced muscle atrophy is sex-specific and not dependent on NFκB, but may involve autophagy differences between males and females.

This study shows that glutamine metabolism in chondrocytes influences inflammatory responses and autophagy, with glutamine deprivation reducing inflammation by inhibiting NF-κB.

This study shows that gasdermin signaling is essential for fracture healing, as its absence delays bone callus formation and reduces biomechanical properties.

This study shows that GSDME compensates for GSDMD deficiency in NLRP3 inflammasomopathy, revealing a GSDME-dependent inflammatory pathway and suggesting dual inhibition of GSDMD and GSDME for therapeutic benefit.