K. Kaur

Broad-spectrum RNA antiviral inspired by ISG15-/- deficiency

The paper identifies a set of 10 ISGs that confer broad-spectrum antiviral resistance and demonstrates their efficacy in protecting against multiple viruses in vivo.

Synovial fluid transcriptome dynamics in osteoarthritis progression: Implications in pathogenesis

This study identifies gene expression changes and pathways involved in osteoarthritis progression using synovial fluid transcriptomes from different OA grades.

A study of machine learning techniques for Automated Karyotyping System

This study reviews machine learning algorithms for improving the classification accuracy of karyotype metaphase images to aid in detecting fetal abnormalities.

Chemotherapy activates inflammasomes to cause inflammation-associated bone loss

This study shows doxorubicin causes bone loss via inflammasome activation, leading to pyroptosis and NETosis, and identifies AIM2 and NLRP3 as key mediators.

Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor binding domain (RBD)

This paper evaluates the stability and immunogenicity of a SARS-CoV-2 RBD VLP vaccine candidate formulated with different adjuvants and finds that AP and AH adjuvants provide comparable immunogenicity to AV, with AP showing higher neutralizing titers.

Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants

Metabolic switching and cell wall remodelling of Mycobacterium tuberculosis during bone tuberculosis

This study identifies transcriptomic changes and virulence factors in Mycobacterium tuberculosis during bone tuberculosis, revealing metabolic shifts and cell wall remodeling strategies for survival in the host.

A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates

This paper describes a protein subunit vaccine candidate produced in yeast that protects non-human primates against SARS-CoV-2, showing high neutralizing antibody titers and reduced viral loads after challenge.

Synthesis, Physiochemical and Biological evaluation of Inclusion Complex of Benzyl Isothiocyanate encapsulated in cyclodextrins for triple negative breast cancer

This study evaluates BITC-CD complexes for triple-negative breast cancer treatment, showing enhanced bioavailability and ROS-mediated cell death.

Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

The paper engineers subunit antigens to improve vaccine manufacturing by reducing variants and enabling single-process production of a trivalent rotavirus vaccine.

In silico analysis of SNPs in human phosphofructokinase, Muscle (PFKM) gene: An apparent therapeutic target of aerobic glycolysis and cancer

The paper computationally identifies functional SNPs in the PFKM gene and associates them with cancer, highlighting potential therapeutic targets.