BiochemistrybioRxiv
Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome
S. h. Park, A. Ayoub, Y. T. Lee…·u.-s. cho
The paper reports the cryo-EM structure of the human MLL1 complex bound to the nucleosome, revealing how it interacts with histone H3K4 and promotes tri-methylation.