PhysiologybioRxivPreprint
The Unexpected Role of GCN2 Kinase Activation in Mediating Pulmonary Vascular Remodeling and Pulmonary Arterial Hypertension
M. M. Zhu, J. Dai, Z. Dai…·Y.-Y. Zhao
This study shows GCN2 kinase activation in hypoxia mediates pulmonary vascular remodeling and PAH via Edn1, suggesting GCN2 as a therapeutic target for PAH.