H. Yao

Phosphate starvation stops bacteria digesting algal fucan that sequesters carbon

The paper shows phosphate starvation reduces bacterial fucan digestion, stabilizing carbon sequestration by algae.

A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan

This study shows that inducing a torpor-like state in mice slows blood epigenetic aging and improves healthspan by reducing core body temperature.

Changes in physicochemical properties and microbial community succession during leaf stacking fermentation

This study examines changes in physicochemical properties and microbial communities during leaf stacking fermentation, identifying key metabolites and microbial interactions.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Dual Ethanolamine Head Groups in Ionizable Lipids Facilitate Phospholipid-free Stable Nanoparticle Formulation for Augmented and Safer mRNA Delivery

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.

Forsythoside A blocks the infection of Avian Infectious Bronchitis Virus through binding S1 subunit

This study shows Forsythoside A inhibits Avian Infectious Bronchitis Virus by binding to its S1 subunit, preventing viral attachment and infection.

Duoculture diminishes social interaction costs and improves growth rates of two fish species at different temperatures

This study shows that duoculture of bluegill and yellow perch improves growth rates and reduces feed conversion ratios, especially at higher temperatures, by lowering social interaction costs.

Gene expression analysis suggests immunosuppressive roles of endolysosomes in glioblastoma

The paper analyzes gene expression in glioblastomas to show endolysosomes in non-tumor cells and immunosuppressive macrophages contribute to a pro-tumorigenic microenvironment.

The effect of bolus properties on muscle activation patterns and TMJ loading during unilateral chewing

This study uses an in silico model to analyze how bolus properties affect muscle activation and TMJ loading during chewing, supporting clinical guidelines for reducing TMJ stress.

Born with intronless ERF transcriptional factors: C4 photosynthesis inherits a legacy dating back 450 million years

This study identifies intronless ERF transcription factors as a molecular tool used in the evolution of C4 photosynthesis in multiple plant lineages.

In situ architecture and membrane fusion of SARS-CoV-2 Delta variant

The paper reports the in situ structure of SARS-CoV-2 Delta variant virions and captures membrane fusion snapshots, revealing unique architectural features and fusion mechanisms.

The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface

This study reports the structures of S. aureus PgsA at two catalytic states, revealing the mechanism of phosphatidylglycerol biosynthesis and the impact of daptomycin resistance mutations.

Comparative genomic analyses provide clues to capsule switch in Streptococcus suis

This study identifies capsule switch in Streptococcus suis strains through comparative genomic analyses, revealing genetic exchange between SS2, SS3, and SS7 strains.

Molecular architecture of the SARS-CoV-2 virus

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2

This study identifies a high-affinity nanobody that, when fused to other nanobodies, enhances their potency against SARS-CoV-2 by improving RBD binding without disrupting RBM conformation.

A potent synthetic nanobody targets RBD and protects mice from SARS-CoV-2 infection

Cross-neutralization antibodies against SARS-CoV-2 and RBD mutations from convalescent patient antibody libraries

Repurposing screen identifies Amlodipine as an inducer of PD-L1 degradation and antitumor immunity

This study identifies amlodipine as a drug that reduces PD-L1 expression and enhances antitumor immunity by blocking calcium flux and autophagic degradation of PD-L1.

Manganese/iron-supported sulfate-dependent anaerobic oxidation of methane by archaea in lake sediments

The paper demonstrates sulfate-dependent anaerobic methane oxidation by Candidatus Methanoperedens archaea in lake sediments, with metal oxides supporting the process under sulfate-starved conditions.

Palmitoylation is critically required for cancer intrinsic PD-1 expression and functions

This study identifies PD-1 palmitoylation, its regulatory enzyme, and develops a peptide inhibitor to target PD-1 expression for cancer immunotherapy.

Convergent recruitment of life cycle regulators to direct sporophyte development in two eukaryotic supergroups

This study shows that TALE HD TFs regulate sporophyte development in two eukaryotic supergroups, indicating an ancient origin of this regulatory system.