imaging

Systems-level imaging reveals assembly and synaptic delivery of a multi-organelle ensemble during T cell killing

The paper uses advanced imaging techniques to study how multiple organelles coordinate during T cell killing, revealing a calcium-driven process of organelle assembly and movement.

Strategies of mechanical adaptations of circulating tumor cells and properties of their cellular microenvironment have predictive and prognostic biomarker value

The paper identifies mechanical adaptations of circulating tumor cells (CTCs) and their microenvironment properties as predictive biomarkers for prostate cancer outcomes.

Diffusion-Based Synthetic Pretraining for Root Segmentation in Rhizotron Images

This paper generates synthetic rhizotron images using diffusion models and shows that pretraining on these images improves root segmentation performance, especially when real annotations are limited.

Bone Response to Mechanical Loading is Highly Heritable and Correlates with Osteocyte Lacunar Morphology in Genetically Diverse Mouse Strains

This study shows that genetic background strongly influences bone response to mechanical loading in mice, with high heritability and correlations with osteocyte lacunar morphology.

Quantitative imaging of native tissue architecture combined with deep multi-omics reveals the spatial biology of kidney aging

This paper introduces NORIGAMI, a multi-omics pipeline that combines imaging and deep learning to analyze kidney aging, revealing age-related structural and molecular changes.

How Well Does Structural MRI Classify Autism? A Leakage-Free, Site-Aware and Externally Validated Machine-Learning Evaluation in Two ABIDE Cohorts

This paper evaluates the accuracy of structural MRI in classifying autism using leakage-free, site-aware, and externally validated machine learning methods across two ABIDE cohorts, finding modest performance.

Nuclear speckles comprise hierarchical nanoscale interaction networks that shape molecular dynamics

This study uses MINFLUX nanoscopy to show nuclear speckles are hierarchically organized into dynamic nanoscale interaction networks that regulate molecular dynamics.

Lymphangiogenesis is Critical for Healing and Survival in a Murine Model of Laryngotracheal Injury

This study shows that lymphangiogenesis is essential for healing and survival after laryngotracheal injury in mice, as blocking it leads to worse outcomes.

Multi-modal in situ profiling of human cells using the AVITI24 platform characterizes single-cell responses to acute stress

The paper uses a multi-modal platform to profile single-cell stress responses in human cell lines, finding a shared stress response program with cell-specific magnitude variations.

In-vivo MRI of noradrenergic and dopaminergic nuclei predicts future cognition and Alzheimers disease progression

The paper uses in-vivo MRI to measure noradrenergic and dopaminergic nuclei integrity in ADNI participants, finding these measures predict future cognitive decline and Alzheimer's progression.

Mitotic centromeres organize in repeat-subunits with specialized histone landscape and multi-domain architecture as revealed by expansion microscopy

The paper uses expansion microscopy to reveal the repeat-subunit organization and multi-domain architecture of human mitotic centromeres, including specialized histone modifications.

When touch leads vision: flexible sensory leadership during active texture exploration

The paper investigates how vision and touch coordinate during texture exploration, finding that touch can lead vision when texture information is critical, but vision takes the lead when visual cues are more informative.

SACHET: seeded contour tracking measures Rab conversion kinetics on individual endosomes in live cells

SACHET tracks individual endosomes in live cells to quantify Rab conversion kinetics, showing rapid switching between Rab5 and Rab7 states across cell lines.

Biomechanical stress in the retinal pigment epithelium surrounding laser scars in humans

The paper investigates how biomechanical stress in the retinal pigment epithelium (RPE) contributes to the enlargement of laser scars over time using imaging and histological analysis.

Expertise modifies neural responses to causal inference during language comprehension

The paper investigates how medical expertise affects neural responses to causal inferences in language comprehension, finding that physicians show stronger activation in animacy-related brain networks during illness-related causal reasoning.

Divergent Pontine and Cerebellar Pathology in Preterm Infants With Necrotizing Enterocolitis

This study identifies divergent brain pathology in preterm infants with NEC, showing distinct cellular and molecular changes in the pons and cerebellum.

MaCADEMIA: a software toolbox for single-molecule fluorescence image quantification

MaCADEMIA is a MATLAB toolbox for single-molecule fluorescence image analysis, providing accurate quantification of molecular properties in living cells.

Differential Survival of Retinal Ganglion Cell Types Following Branch Retinal Vein Occlusion

In a mouse branch retinal vein occlusion model, retinal ganglion cells die progressively over 14 days. α-RGCs and F-RGCs are lost fastest, and TBR2-positive intrinsically photosensitive RGCs survive best.

Infection-related images reduce cortical edge metastability: a specification-curve analysis of a block-design fMRI study

The paper analyzes fMRI data to show that infection-related images reduce cortical edge metastability, with significant results surviving multiple corrections.

Born on Mars: Multigenerational phenotypic change in Caenorhabditis elegans under Martian analog gravity and hypomagnetic fields

This study examines transgenerational effects of Martian analog gravity and hypomagnetic fields on C. elegans, finding progressive impairments and increased phenotypic variability across generations.

Differential and regionally distinct molecular responses distinguish FLASH and conventional RT in a medulloblastoma model while preserving therapeutic outcomes

Hypo-fractionated FLASH and conventional radiotherapy (3x10 Gy) each ablated orthotopic human medulloblastoma in nude mice; FLASH evoked distinct microglial and hippocampal transcriptional programs and less neuroinflammation.

Low-pass filtering revisited: ramped phase randomization for cryo-EM map comparison and data augmentation

This paper introduces ramped phase randomization to improve cryo-EM map comparison and data augmentation by reducing fine-scale detail while preserving low-frequency content and enhancing machine learning performance.

Molecular MRI of Neuroinflammation in Alzheimer's Disease using a Folate-targeted Nanoprobe

This study uses a folate-targeted nanoprobe to image neuroinflammation in Alzheimer's disease models via molecular MRI, showing enhanced signal in transgenic mice with pro-inflammatory microglia.

Variability and Landmark Quality in Anatomical Co-Registration in Neuronavigation for Brain Stimulation

This study quantifies variability in anatomical landmark localization during neuronavigation, showing operator- and landmark-specific differences and the impact of marking on inter-operator agreement.

Superior Frontal Gyrus Cortical Thickness Mediates the Association Between Openness to Experience and Theory of Mind: Evidence from the Human Connectome Project

The ViRA-L (Visual Recognition Assessment-Leuven): Development, Validation, and Age Stratified Normative Characterization of a Multi-Category Visual Recognition Battery

The paper develops and validates the ViRA-L, a visual recognition battery with age-stratified norms, showing good reliability and age-related category-specific differences.

Mapping bioimage-analysis software adoption in microscopy

The paper tracks the adoption of bioimage-analysis software across 1.7 million microscopy papers from 2010 to 2025, finding increased usage and concentration on general-purpose platforms like ImageJ/Fiji.

Visualization and Morphological Analysis of Individual Oligodendrocytes in the Mouse White Matter

The paper describes methods to visualize and analyze the morphology of individual oligodendrocytes in mouse white matter using genetic labeling and immunostaining techniques.

NDE1 Localizes to the Subdistal Appendages to Maintain Centrosome Integrity and Microtubule Organization

This study identifies NDE1's localization at subdistal appendages and shows its role in maintaining centrosome integrity and microtubule organization through interactions with other proteins.

Levodopa induced dyskinesia severity is linked to distinct microstructural alterations in nigrostriatal and brainwide neural circuits

This study investigates how L-DOPA-induced dyskinesia (LID) relates to microstructural changes in brain circuits, finding brainwide alterations beyond the nigrostriatal system.