human

The paper identifies ROR1 activation as a key pathway mediating the protective effects of NMDAR antagonists on pancreatic islet cells through phosphoproteomics and kinase profiling.

This study introduces a co-aggregation method to improve morphogenesis and lineage representation in human stem cell-based embryo models.

This study shows HPV oncogenes alter DNA repair mechanisms in HNSCC, creating a vulnerability to therapies targeting RAD51 filament dynamics.

The paper develops RIZLiver to infer zonal identity from gene expression in liver disease, showing loss of zone-3 identity in MASLD and therapeutic potential through zonal restoration.

This study uses long-read whole genome sequencing and pangenomes to identify novel variants and pathogenic findings in neurodevelopmental disorder cases from underrepresented populations.

This study shows that identical movements can form different skills depending on context, observed in both humans and neural networks.

This paper identifies three therapeutic axes for MBD4-deficient tumors using a multi-layered framework, showing sensitivity to ATR inhibitors and cytidine analogs but not PARP inhibitors.

DECODE decomposes brain functional states into structure-coupled and decoupled components, revealing AD-related differences in temporal dynamics and connectivity organization.

This paper develops a method to sustain Tie2 activation using engineered mRNA, showing improved endothelial stabilization compared to traditional ligands.

This study shows that SOX7 and ERG reprogram human pluripotent stem cell-derived cells into brain endothelial cells with forebrain regional bias, improving BBB modeling.

This paper introduces xGL-APMS to profile endogenous galectin-3 interactions at the cell surface, identifying 125 interactors on Jurkat cells and 69 on mouse thymocytes.

This study determines the structure of full-length human hephaestin using cryo-EM, revealing its homodimeric organization and substrate-binding site.

This study shows PKR inhibition reduces apoptosis in DYT-PRKRA cells by blocking CHOP induction, suggesting it as a potential therapy for this dystonia.

This paper identifies a SOX9 C-terminal module that recruits cBAF to enhancers, controlling cell state by remodeling chromatin.

This paper introduces RIDGE, a deconvolution framework that generates spatially continuous cell-type maps of the human cortex, revealing both global organization and regional specialization.

The paper identifies rare coding variants enriched in cognitive superagers by comparing whole-exome sequencing data to controls and a population reference database.

The paper identifies retained-region transcript architectures and region-dependent nucleolar enrichment of lncRNAs in colorectal cancer using integrated multi-omics approaches.

The paper identifies NPM1::ALK-derived circular RNAs that promote aggressiveness in ALK-positive anaplastic large cell lymphoma by modulating cytokine signaling and myeloid remodeling.

This study identifies HERC1 substrates through proteomic analysis, revealing its role in proteasome homeostasis and linking its dysfunction to neurodevelopmental disease.

This study shows that PPI-associated microbiome changes cause systemic metabolic and transcriptional responses, affecting metabolism and inflammation in multiple tissues.

The paper identifies LCK-driven EGFR activation as a therapeutic target in cholangiocarcinoma, showing EGFR activity predicts response to EGFR inhibition.

This study shows that speech motor cortex encodes sentence-level linguistic structure and semantic content through single-unit activity in three BrainGate2 participants.

This study identifies genetic factors associated with self-reported SSRI response in depression using genome-wide meta-analysis and polygenic scores, highlighting GABAergic and glutamatergic pathways.

This study uses AI to identify BMI-associated morphologic features in breast cancer tissue, finding that high BMI is linked to distinct stromal patterns and reduced inter-patient heterogeneity.

This study characterizes the neuroblastoma immune microenvironment, finding limited T cell infiltration, abundant macrophages with targetable receptors, and associations between immune composition and patient survival.

This study uses sedimentary ancient DNA to expand bioarchaeological insights at Roman Harelbeke, revealing broader biological signals and environmental taxa not captured by traditional methods.

This study introduces DynaClade, an algorithm for analyzing human motion in virtual environments, revealing non-random action sequences with higher-order structure and context-dependent behavior.

This study shows that long-term estrogen deprivation protects against acetaminophen-induced liver injury through lipid remodeling and sustained NRF2 activation.

This study shows that partial reprogramming leads to different recovery outcomes in human fibroblasts, T cells, and endothelial cells, revealing lineage-specific tradeoffs between rejuvenation and recovery.