Mitochondrial Function and Pathology

This study shows that cardiolipin remodeling is essential for maintaining inner mitochondrial membrane structure in yeast under low oxygen conditions and identifies Ddl1p as a regulator of CL levels.

The paper identifies ITPRIPL2 as a novel protein involved in mitochondrial dynamics through computational interaction analysis and shows its role in vimentin-associated intermediate filament structure.

The paper investigates mitochondrial lactate metabolism, finding that mitochondria produce lactate as an overflow mechanism to regulate redox levels and conserve energy.

The paper studies mitochondrial structural diversity in C. elegans neuromuscular system across development using 3D electron microscopy and deep learning, finding correlations between mitochondrial properties and synaptic connections, and identifying stage-specific mitochondrial features in dauer.

The paper shows that the Cell Painting assay can detect mitochondrial stress and predict mitochondrial toxicity in small molecules.

This study shows that mitochondrial supercomplex formation reduces membrane strain and enhances allosteric crosstalk, with implications for OXPHOS efficiency.

The paper shows amino acids trigger MDC-dependent mitochondrial remodeling by altering mitochondrial metabolism and TCA cycle metabolite levels.

The paper identifies repurposable drugs for mitochondrial disease by using deep learning to screen for compounds that improve neuronal commitment and neurogenesis in Leigh syndrome organoids.

This study identifies NCLX as the primary mitochondrial Ca2+ extruder in hepatocytes, linking hormone-mediated mitochondrial Ca2+ oscillations to gluconeogenesis.

The paper investigates mitochondrial protein import in Cyanidioschyzon merolae by designing synthetic targeting peptides and showing that basic residues and specific amino acid composition are sufficient for import, with a simplified authentication mechanism involving TOM22.

The paper identifies a conserved post-birth metabolic switch in vertebrates characterized by elevated mitochondrial and nuclear gene expression across multiple tissues.

The paper investigates mitochondrial distribution changes in Drosophila neurodegeneration, finding altered mitochondrial localization at the axon initial segment associated with reduced Cdk5 activity.

The paper identifies METEORs, mitochondria specialized for filopodia, and shows their role in supporting cellular migration.

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

This study uses CRISPR/Cas9 screening to identify novel regulators of mitochondrial oxidative metabolism, revealing key genes involved in complex I assembly and BCAA catabolism.

This paper models ATP concentration dynamics in presynaptic boutons with and without stationary mitochondria, finding that ATP levels remain sufficient for synaptic activity even without mitochondria.

This study links psychosocial experiences to mitochondrial biology in the human brain, finding positive experiences correlate with higher OxPhos machinery abundance and negative experiences with lower abundance.

This study investigates age-related changes in mitochondrial function and cytoplasmic viscosity in mouse peripheral neurons, finding compartment-specific effects on mitochondrial trafficking and homeostasis.

This study uses nanobiopsy and next-generation sequencing to assess subcellular mtDNA mutation loads in human tissue from mitochondrial disease patients.

This study shows that Drp1-mediated mitochondrial fragmentation ensures symmetric organelle partitioning and faithful chromosome segregation in mouse zygotes.

This study defines the structural basis of a regulatory switch in mammalian complex I by combining cryoEM structures with biochemical analysis, showing how conformational changes mediate deactivation during ischaemia.

This study uses patient-derived iPSCs and organoids to show mitochondrial dysfunction and oxidative stress in AT, which can be mitigated by ATM correction or antioxidants.

This study uses molecular dynamics simulations to assess how single or combined missense variants in respiratory complex I affect its function, finding that some variants stiffen key regions and worsen dysfunction.

The paper profiles mitochondrial activity, morphology, and associated molecular changes during zebrafish embryogenesis, identifying increased ER-mitochondria contacts and mitochondrial fusion as key contributors to mitochondrial activation.

This study shows that loss of Xin in mice leads to altered mitochondrial morphology and function in skeletal muscle, without affecting mitochondrial dynamics.

This study examines sex- and age-specific gene expression influenced by mitochondria in a species without sex chromosomes, finding sex-dimorphic energy metabolism and mito-nuclear interactions.

The paper shows that neuronal activity inhibits axonal mitochondrial transport in specific axonal regions during realistic firing patterns, but not in non-connecting segments.

This study develops nanobodies to monitor Drp1, a mitochondrial fission factor, using proteomics, microscopy, and live-cell imaging techniques to study its dynamics in disease models.

This paper develops an extracellular flux analysis to study mitochondrial respiration and energy metabolism in isolated renal tubules, showing transport activity regulates mitochondrial bioenergetics and biogenesis.

This study determines the structure of a unique II2-III2-IV2 mitochondrial supercomplex from Perkinsus marinus using cryo-EM, revealing novel subunit arrangements and functional features.