Immunotherapy and Immune Responses

Duality Vaccination through Nanodesign of Click-Ligated B-Cell Inhibitory Receptor Bridging

This paper introduces Duality vaccination, a method that delivers both activating and inhibitory stimuli to shape antibody responses, using nanoparticle-based immunogens.

MHC II-expressing bone marrow megakaryocytes are noncanonical antigen presenting cells and activate CD4+ T cells ex vivo

The paper identifies MHC II-expressing bone marrow megakaryocytes as noncanonical antigen-presenting cells capable of activating CD4+ T cells and modulating immune responses.

Vaccination targeting the novel endogenous tumor-associated antigen Gpr149 induces protective immunity against checkpoint inhibitor-refractory SB28 glioblastoma

This study identifies Gpr149 as an endogenous antigen in SB28 glioblastoma that can be targeted by vaccination to induce protective immunity against checkpoint inhibitor-refractory tumors.

Astatine-211 injury induces an immunostimulatory melanoma-cell state and promotes systemic antitumor immunity

This study shows that astatine-211 injury to melanoma cells induces an immunostimulatory state that promotes systemic antitumor immunity by activating type I interferon and inflammatory pathways.

Sequential engagement of distinct dendritic cell subsets shapes Th2 polarization

The paper shows that distinct dendritic cell subsets sequentially engage CD4 T cells during priming, with late CD70 DC2s driving Th2 polarization.

Antigen recognition licenses therapeutic CD8+ T cells to organize a multicellular myeloid interaction network in the tumor microenvironment

This study investigates how therapeutic CD8+ T cells interact with myeloid cells in the tumor microenvironment through antigen recognition, revealing state-selective networks and the role of pMHC-I sources.

Live immunogenic melanoma cells generated by etoposide treatment upregulate B2M and lose tumor-forming potential

This study shows that etoposide-treated B16-Ova melanoma cells upregulate B2M and lose tumor-forming potential while remaining viable and stimulating T-cell activation.

Improved anti-tumor vaccination activity of necroptotic cells lacking ATG16L1-dependent unconventional autophagy

This study shows that blocking ATG16L1-mediated unconventional autophagy in necroptotic tumor cells enhances their ability to induce anti-tumor immunity by increasing ATP secretion and T cell infiltration.

Combining an autoactivated cGAS mutant with membrane-tethered IL-12 via mRNA lipid nanoparticles promotes systemic tumor control

This paper combines an autoactivated cGAS mutant with membrane-tethered IL-12 via mRNA LNPs to promote systemic tumor control in mouse models.

Discovery of frameshift-associated TCRs following personalized neoantigen vaccination in a patient with osteosarcoma

The paper reports the discovery of TCRs specific to vaccine peptides in a patient with osteosarcoma following personalized neoantigen vaccination and in vitro expansion.

In vitro-generated murine monocyte-derived dendritic cells habor a unique identity compared to other mononuclear phagocytes, largely conserved with their human and putative in vivo counterparts.

This study generates a transcriptomic atlas of in vitro-derived mononuclear phagocytes to clarify the identity of moDCs and their in vivo counterparts.

A Framework for Comparing Mouse Neoantigen Immunogenicity

Experimental pMHC melting-temperature stability ranked in vivo CD8+ T cell responses of 25 mouse neoantigens better than affinity assays or nine in silico predictors.

T cell engagers convert acute tumor killing into endogenous vaccination

This study shows that T cell engagers induce endogenous vaccination by triggering a cytotoxic wave and cross-priming of CD8 T cells via dendritic cells.

CXCR3 on transferred T cells enables vaccine-boosted adoptive T-cell therapy in solid tumors

This study shows that CXCR3 on transferred T cells enhances the effectiveness of combining adoptive T-cell therapy with viral-vector vaccines in solid tumors.

Programmable antigen-presenting scaffolds expand rare tumor-antigen-specific T cells from peripheral blood

This paper introduces APC-ms, a platform that expands rare tumor-antigen-specific T cells from peripheral blood, achieving higher enrichment and functional properties compared to conventional methods.

Human CD4 T cells coordinate antitumor immunity through indirect antigen presentation

This study shows human CD4 T cells can drive antitumor immunity in MHC class II-negative cancers through indirect antigen presentation via APCs.

Turning aging cells into a live vaccine: engineered senescent cancer cells with adjuvant celecoxib for immunotherapy

This study develops a live vaccine using engineered senescent tumor cells and celecoxib to enhance immunotherapy against melanoma and pancreatic tumors.

Contextual control of CD8+ T cell priming by dendritic cell subsets in tumor and inflammatory microenvironments

This study shows that migratory type 1 dendritic cells are more effective than lymph node resident type 1 dendritic cells in priming CD8+ T cells in tumor and inflamed tissues.

Lysophosphatidylserine Nanoparticles Induce Oral Tolerance Independent of TIM-4 and Canonical PS Processing

This study shows that lysophosphatidylserine nanoparticles induce oral tolerance without requiring TIM-4 or canonical PS processing.

Radiation therapy synergizes with mRNA vaccination to overcome microglia-mediated suppression of dendritic cell migration and T cell priming in glioblastoma

Spatiotemporal control of STING activation and saRNA delivery decouples humoral and cellular immunity

This study shows that timing and location of STING activation relative to saRNA delivery affects humoral and cellular immune responses, with synchronized delivery enhancing T cell responses without impacting antibody production.

Cell painting with amphiphile-protein conjugate vaccines drives B cell activation and germinal center priming to enhance humoral immunity

Atomic layer deposition for core-shell microparticle vaccines enabling programmable antigen delivery and enhanced humoral immune responses

This study develops ALD-coated microparticles for vaccines that enable controlled antigen release and enhance immune responses against HIV.

Oxygen-generating cryogel vaccines help overcome tumor antigen tolerance and induce durable anti-tumor immunity in prostate cancer

This study develops a cryogel vaccine platform that generates oxygen to overcome tumor antigen tolerance and induce durable anti-tumor immunity in prostate cancer.

Improving peptide vaccine manufacturability without sacrificing immunogenicity: substitution of methionine and cysteine with oxidation-resistant isosteres

This study introduces oxidation-resistant (OXR) antigens by substituting cysteine and methionine with isosteres to improve peptide vaccine manufacturability without compromising immunogenicity.

Phase-resolved transcriptomic bottlenecks in peptide cancer vaccine response

The paper analyzes transcriptomic data from three peptide-vaccine cohorts to identify phase-linked immune response layers associated with vaccine efficacy and survival outcomes.

LNP-CpG: deploy the self-adjuvant role of mRNA vaccines

This study demonstrates that LNP-CpG enhances immunogenicity of subunit vaccines in mice and non-human primates, outperforming existing vaccines and showing broad applicability across vaccine platforms.

Targeting glucocorticoid signalling in dendritic cells for glioblastoma treatment

This study identifies glucocorticoid signalling as a barrier to dendritic cell immunotherapy in glioblastoma and shows that targeting NR3C1 can restore DC function and enhance anti-tumor responses.

Personalized Neoantigen Vaccines Synergize with Immune Checkpoint Therapy and CD8-Targeted Cytokines to Control B-Cell Lymphoma

This study shows that personalized neoantigen vaccines combined with immune checkpoint therapy and CD8-targeted cytokines effectively control B-cell lymphoma by enhancing T-cell responses and preventing dysfunction.

Comprehensive transcriptomic profiling uncovers an inflammatory maturation program conserved in human and mouse dendritic cells

The paper identifies a conserved inflammatory maturation gene program in human and mouse dendritic cells that extends beyond immature-versus-mature classification.