Robert A. Seder

This study introduces oxidation-resistant (OXR) antigens by substituting cysteine and methionine with isosteres to improve peptide vaccine manufacturability without compromising immunogenicity.

This paper improves an anti-malaria antibody to broaden its recognition of malaria parasite proteins and enhances its protective effectiveness against diverse strains.

This study shows that stem-like CD8+ T cells, when used in adoptive cell therapy followed by vaccination, improve tumor control by altering the tumor microenvironment's transcriptomic profile.

This study shows that nanoparticle vaccines with oligomannose glycans boost B cell responses and protection against malaria sporozoites compared to other glycan types.

This paper develops a nanoparticle-based junctional vaccine targeting PfCSP and compares its efficacy to the R21 vaccine in reducing malaria liver burden in mice.

This study shows that antibodies against Mtb enhance immunity via NLRP3 inflammasome activation in mice, independent of Fc receptors, and this mechanism applies to polyclonal sera in rhesus macaques.

This study maps polyclonal antibody responses to mRNA-1273 and NVX-CoV2373 vaccines using EMPEM, revealing the NTD supersite as an immunodominant epitope vulnerable to variant mutations.

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

The paper shows that CD4 T cells and innate CD8+ lymphocytes are essential for IV BCG-induced protection against tuberculosis in macaques.

The paper identifies a humoral correlate of protection against tuberculosis in humans and non-human primates, showing cross-species and vaccine regimen consistency.

The paper uses Markov Fields to integrate multi-modal immune data from vaccinated macaques, identifying critical immune interactions and predicting perturbation effects.

This study shows that mucosal adenoviral-vectored vaccines provide durable protection against XBB.1.16 infection in nonhuman primates, outperforming intramuscular boosting in reducing virus replication in both upper and lower airways.

The paper shows that eosinophils protect against SARS-CoV-2 in vaccinated mice during breakthrough infections by reducing viral burden and limiting dissemination.

The paper evaluates the depletion of T cell subsets in nonhuman primates using monoclonal antibodies, finding substantial depletion in blood and tissue with residual cells often remaining in tissue.

This study shows a gorilla adenovirus-based vaccine provides durable immunity against SARS-CoV-2 in both airways of non-human primates, with enhanced protection from aerosol delivery and prime-boost regimens.

This study investigates how clonal hematopoiesis affects COVID-19 severity and pathophysiology in rhesus macaques, finding prolonged inflammation and higher viral persistence in CH animals.