Streptococcal Infections and Treatments

Streptococcus pyogenes transforms the salivary proteome during controlled human infection

This study identifies changes in the salivary proteome during Streptococcus pyogenes infection, revealing inflammatory responses and virulence factor interactions.

Diversity of penicillin-binding protein 2x in Streptococcus pyogenes from England and Wales, 2001 to 2015

The paper analyzes PBP2x sequence diversity in S. pyogenes isolates from England and Wales, finding mutations associated with reduced beta-lactam susceptibility and macrolide resistance.

Survival of Streptococcus anginosus in blood is linked to hydrogen peroxide production

This study identifies hydrogen peroxide production as a key factor enhancing survival of Streptococcus anginosus in human blood.

SpxA1 and SpxA2 Function as a Stoichiometry-Dependent Regulatory Rheostat Governing Virulence Gene Expression in Group A Streptococcus

This study identifies SpxA1 and SpxA2 as regulators of virulence gene expression in GAS, showing their stoichiometric balance determines transcriptional programs through interactions with CovR.

High resolution Streptococcus pyogenes core genome MLST and LIN coding scheme for outbreak detection

The paper introduces a high-resolution core genome MLST and LIN coding scheme for Streptococcus pyogenes to improve outbreak detection through scalable and sharable genetic relatedness analysis.

Vav2 is a master regulator of repair against bacterial pore-forming toxins.

This study identifies Vav2 as the master regulator of Ca2+-dependent repair against bacterial pore-forming toxins in necrotizing soft tissue infections.

Gram-negative-dominated polymicrobial microbiome of necrotizing soft tissue infections from North India: an integrated culture and 16S rRNA metagenomics prospective cohort study

This study identifies a Gram-negative-dominated microbiome in North Indian necrotizing soft tissue infections, contrasting with the Western paradigm dominated by Streptococcus pyogenes.

Pangenomic decomposition reveals lineage-specific immune-evasion and virulence architectures in group A Streptococcus

This paper uses pangenome decomposition to reveal lineage-specific immune-evasion and virulence architectures in group A Streptococcus, showing that virulence factors are organized into distinct modules.

Streptococcal superantigen SpeC induces IL-8 secretion in human epithelial cells

This study shows that SpeC induces IL-8 secretion from human epithelial cells via Erk1/2, p38 MAPK, and NF-κB signaling pathways.

A protease-sensing circuit links neutrophil inflammation to virulence regulation in Streptococcus pyogenes

This study identifies a protease-sensing circuit in Streptococcus pyogenes linking neutrophil inflammation to virulence regulation through SpeB and Vfr interactions.

Molecular analysis of Lancefield group C/G streptococci causing human infections in Sheffield, UK.

This study performs whole-genome sequencing of Lancefield group C/G streptococci isolates from Sheffield, UK, revealing high genomic diversity, antimicrobial resistance, and persistence within hosts.

Lysosomal permeabilization by Group A Streptococcus releases proteins into the macrophage cytosol

This study shows that Group A Streptococcus perforates macrophage phagolysosomes, releasing both host and bacterial proteins into the cytosol, which triggers inflammatory responses and contributes to disease pathology.

Structural and Immunological Alterations at the Human Cribriform Plate in Streptococcus pyogenes Meningitis: A Case Study

This paper describes a case study of Streptococcus pyogenes meningitis, highlighting structural and immunological changes in the cribriform plate and their implications for CNS immune response.

Attenuated interferon signalling in alveolar epithelium limits resistance to Streptococcus pyogenes

This study compares S. pyogenes infection responses in airway and alveolar epithelial cells, finding that alveolar cells show higher cell death and a pro-inflammatory response without cytokine secretion, and that IFN-β treatment reduces infection.

Structural mechanisms for the recruitment of factor H by Streptococcus pyogenes

This study identifies structural mechanisms by which Streptococcus pyogenes recruits factor H through M proteins and FbaA, revealing conserved and variable binding patterns across strains.

A teichoic acid-like wall modification associated with immune suppression is socially regulated in Streptococcus pyogenes

This paper identifies a teichoic acid-like cell wall modification in Streptococcus pyogenes that mediates immune suppression and is regulated by quorum sensing.

Gene contribution of Streptococcus dysgalactiae subspecies equisimilis, an emerging pathogen, to experimental primate necrotizing myositis

This study identifies essential and conditionally essential genes in SDSE using TraDIS in vitro and in vivo, highlighting nutrient acquisition as critical for infection.

M1 protein expression determines niche-specific spread of Streptococcus pyogenes

This study shows that secreted M protein, not cell-surface M protein, is critical for lymphatic survival and systemic infection of Streptococcus pyogenes in mice.

Genomics of Irish swine-derived Streptococcus suis: Population structure, prophages, and anti-viral defence mechanisms

This study characterizes 110 Irish Streptococcus suis strains using whole-genome sequencing to explore population structure, prophages, and anti-viral defense mechanisms.

Genome-Wide Identification of Conditionally Essential Genes Supporting Streptococcus suis Growth in Serum and Cerebrospinal Fluid

This study identifies conditionally essential genes for Streptococcus suis growth in serum and cerebrospinal fluid using Tn-Seq and Nanopore sequencing.

Glycerol suppresses lactose-dependent growth of Streptococcus pyogenes through a transcription-independent mechanism

This study shows glycerol inhibits lactose-dependent growth in Streptococcus pyogenes without affecting transcription, while lactose induces distinct transcriptional responses.

Global genome analysis identifies glycolipids and lipoteichoic acid alanylation as contributors to Group B streptococcal diabetic wound infection

The paper identifies glycolipids and lipoteichoic acid alanylation as factors contributing to Group B streptococcal diabetic wound infection using a transposon mutant screen in a murine model.

Unraveling Streptococcus pyogenes Carriage: Genomic and Transcriptomic Insights from Acute and Post-Treatment Phases

This study analyzes genomic and transcriptomic data from Streptococcus pyogenes during acute infection and post-treatment carriage, finding distinct gene expression patterns but no carrier-specific genotypes.

Phylodynamics and genome-wide association studies reveal the expansion of modern Streptococcus canis in Germany

This study analyzes 585 Streptococcus canis isolates to identify genetic factors driving its expansion, finding two dominant lineages associated with increased pathogenicity and host adaptation through genetic exchange with other streptococcal species.

Streptococcus pyogenes nuclease A interferes with host complement functions

This study identifies SpnA's role in inhibiting the complement system by interacting with C5b67, preventing membrane attack complex assembly.

Ectopic expression of the sensor CovS cytosolic domain confers phosphatase activity and full virulence to the M1T1 CovSY39H attenuated variant of group A Streptococcus

This study shows that ectopic expression of the CovS cytosolic domain restores phosphatase activity and virulence to an attenuated GAS variant, demonstrating the critical role of CovS phosphatase in virulence regulation.

Identifying Genetic Variations in emm89 Streptococcus pyogenes Linked to Severe Invasive Infections

The paper identifies genetic variations in emm89 Streptococcus pyogenes associated with invasive infections using genome-wide association studies and validates one mutation's effect on bacterial growth.

Natural variation of the streptococcal Group A carbohydrate biosynthesis genes impacts host-pathogen interaction

The paper identifies genetic variation in the gacA-L cluster of S. pyogenes and shows that inactivating mutations in gacH reduce GroP decoration, affecting host-pathogen interactions.

Sub-clinical exposure to Streptococcus pyogenes drives the development of immunity

The paper shows that sub-clinical exposure to Streptococcus pyogenes generates functional immune responses and contributes to immunity by adulthood.

Emergence of zoonotic and multi-drug resistant Streptococcus suis

This study identifies the emergence and evolution of two zoonotic Streptococcus suis lineages in Thailand, showing they acquired multi-drug resistance and serotype 2 capsule through horizontal gene transfer.