Ferroptosis and cancer prognosis

This study shows that reducing ACACA expression suppresses oral cancer growth and enhances cisplatin's effect on ferroptosis.

This study shows that GPX4 inhibitor sensitivity differs between 2D and 3D cultures due to lipid composition changes, with 3D cultures showing resistance through PUFA displacement by MUFAs.

This study shows FLASH RT increases lipid peroxidation and ferroptosis in tumors but not normal tissues, and high-iron diets negate FLASH's protective effect in normal tissues.

This study identifies riboflavin as a modulator of ferroptosis sensitivity by supporting FSP1 stability and antioxidant recycling, with implications for therapeutic targeting.

This study shows that inhibiting cap-dependent translation in lymphoma cells increases sensitivity to ferroptosis and CAR-T therapy by reducing NRF2 expression.

This study investigates how dietary restriction and exercise affect ferroptosis in different muscle types during obesity, finding fiber-type-specific regulation through GPX4.

This study investigates how sulfasalazine induces ferroptosis via PDI-mediated iNOS activation and NO accumulation in rat cell lines.

Scutellarin suppresses RSL3- and erastin-induced ferroptosis in human HK-2 cells and mouse macrophages via Nrf2 upregulation, and reduces folic acid-induced kidney injury in mice.

This study identifies glycosaminoglycan-mediated lipoprotein uptake as a mechanism by which cancer cells resist ferroptosis and lipid oxidative stress.

The paper identifies SLC7A11-mediated cysteine metabolism as a target to overcome trastuzumab resistance in HER2 positive breast cancer by inducing ferroptosis.

The paper establishes a murine model of iron overload-induced hepatic ferroptosis and identifies a gene signature that predicts ferroptosis-related liver damage in both mice and humans.

This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.

This study shows that protein S-glutathionylation protects cells from ferroptosis by maintaining ARF6 function and reducing labile iron pools.

The paper shows chemoresistant cancer cells are vulnerable to ferroptosis due to iron dysregulation, despite varying ferroptosis sensitivity in untreated cells.

This study shows that LxA4/FPR2 signaling reduces ferroptosis in alveolar epithelial cells via NRF2 activation, protecting against lung ischemia-reperfusion injury.

This study shows ferroptosis contributes to hyperuricemic nephropathy by activating RAGE signaling, and inhibiting ferroptosis improves renal injury and fibrosis in a mouse model.

This paper introduces ruthenosomes, engineered ruthenium complexes that induce ferroptosis by enhancing ROS levels and activating ferritinophagy, effectively suppressing colorectal tumor growth.

This study identifies two subtypes of colon cancer based on ferroptosis and cuproptosis-related genes, develops a prognostic signature, and evaluates its clinical utility and therapeutic implications.

This study shows ferroptosis inhibition improves cardiac function and metabolism in a large animal model of right heart failure.

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

The paper uses global subcellular proteomics to identify subcellular-specific anti-ferroptotic responses in A549 cells exposed to ionizing radiation, highlighting potential mechanisms of radio-resistance.

This study integrates single-cell and bulk RNA-seq data to identify ferroptosis-related genes in TNBC, developing a risk score model to predict prognosis and guide drug selection.

The paper shows PRDX6 influences ferroptosis sensitivity by managing cellular selenium levels, which affects GPX4 function.

The paper shows lipid-starved cancer cells are more sensitive to ferroptosis due to increased PUFA trafficking into phospholipids, challenging the assumption that PUFA levels directly determine ferroptosis susceptibility.

This paper shows NINJ1 protects cancer cells from ferroptosis by interacting with xCT antiporter and modulating CoA and GSH levels.

This study shows that DDI2 activates NFE2L1 to protect cells from ferroptosis by regulating the ubiquitin-proteasome system.

This study identifies Gpx4 and ferroptosis-suppressing pathways as key to cold resistance in hibernator cells, showing their potential to enhance cold tolerance in non-hibernators.

This study shows RSL3 induces ferroptosis in HT22 cells by inhibiting TrxR1, activating PDI, and promoting NOS dimerization and NO accumulation.

This study identifies RUNX2 isoform II as a suppressor of ferroptosis and apoptosis in OSCC by upregulating PRDX2 via the HOXA10/RUNX2 isoform II/PRDX2 pathway.