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This study identifies NMRAL2P as an NRF2-induced long noncoding RNA that regulates NSCLC proliferation through a distinct gene expression program separate from NRF2's antioxidant effects.

The paper engineers a highly efficient PAMless genome editing system, eTasR, which significantly improves editing efficiency in mammalian cells and enables in vivo gene disruption.

This paper develops a single-AAV vector for cardiomyocyte-specific adenine base editing to correct a mutation causing HCM in mice, achieving therapeutic effects at lower doses than dual-AAV approaches.

The paper shows that integrin-expressing cells can take up latent TGF-β1 via trogocytosis, convert it into an active signaling molecule, and relay signals to bystander cells.

The paper identifies ROR1 activation as a key pathway mediating the protective effects of NMDAR antagonists on pancreatic islet cells through phosphoproteomics and kinase profiling.

The paper presents the first high-resolution structure of a conjugative pilus tip from the R388 T4SS, revealing a structural mechanism that couples tip contact to channel opening and identifies convergent principles in bacterial secretion systems.

This study shows HPV oncogenes alter DNA repair mechanisms in HNSCC, creating a vulnerability to therapies targeting RAD51 filament dynamics.

The paper develops RIZLiver to infer zonal identity from gene expression in liver disease, showing loss of zone-3 identity in MASLD and therapeutic potential through zonal restoration.

The paper introduces coarse-tuning to specialize a protein foundation model for a specific domain, showing improved performance on transfer learning tasks using a medium-sized dataset of outer membrane beta barrels.

This study shows PKR inhibition reduces apoptosis in DYT-PRKRA cells by blocking CHOP induction, suggesting it as a potential therapy for this dystonia.

This study develops a CNTF-VG1 fusion protein to extend ocular retention of CNTF, showing improved vitreous stability and neuroprotection in glaucoma models.

This study identifies HERC1 substrates through proteomic analysis, revealing its role in proteasome homeostasis and linking its dysfunction to neurodevelopmental disease.

The paper identifies Sgl{varphi}Cb5 as targeting MraY and shows convergent evolution between ssRNA and ssDNA phage Sgls.

This paper develops an extraction-free qPCR workflow for direct whole-blood testing of viral pathogens, achieving detection limits of 10 copies/uL for DNA and 100 copies/uL for RNA in spiked blood samples.

This study shows increasing PCAF-1 in C. elegans extends lifespan, preserves healthspan, and enhances stress responses by reprogramming transcription and improving proteostasis.

The paper introduces combined-FISH to quantify antibiotic resistance gene copy numbers in single bacterial cells and links them to host identity in complex environments.

This paper engineers the CasX-Editor to create a more potent and specific genome editor for therapeutic use, showing improved activity and reduced off-target effects in nonhuman primates.

This paper identifies a universal AT2 cell marker, NaPi2b, and introduces upifitamab, a humanized monoclonal antibody, enabling cross-species AT2 cell isolation with high purity.

This study evaluates N8-propargyl spermidine as a chemical probe for hypusination and challenges claims of expanded DHS substrate specificity.