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This study shows that Klf4-dependent transitions in adventitial progenitor cells affect plaque stability in atherosclerosis by altering fibroblast, SMC, and macrophage phenotypes.

This study shows niacinamide enhances LL37's ability to disrupt SARS-CoV-2 membranes, suggesting it could improve AMP-based therapies for COVID-19.

The paper identifies 580 drug candidates with similar activities to prednisolone in SMA models using transcriptomics and drug repositioning, but only some show potential as SMA treatments.

This paper develops a deep learning pipeline for automated AML diagnosis and molecular characterization using flow cytometry data, achieving high accuracy in classification and variant prediction.

This study shows that O-GlcNAcylation is essential for hepatocyte differentiation and its loss promotes liver fibrosis and hepatocellular carcinoma.

This study shows that β-catenin inhibition disrupts osteogenic/adipogenic differentiation in bone marrow mesenchymal cells, contributing to glucocorticoid-induced osteonecrosis of the femoral head.

The paper develops a deep learning method to predict spatial transcriptomics data from H&E images using graph neural networks and Vision Transformers, identifying 250 breast cancer-related genes.

This study uses SSR markers to analyze genetic differentiation in Phyllachora maydis populations across the Midwest U.S., finding significant but low genetic differentiation and evidence of sexual recombination.

This paper develops a deep learning model using QSM to differentiate gold fiducial markers from calcification in prostate cancer patients, achieving higher accuracy than conventional MRI methods.

This study shows that periodontitis promotes neuroinflammation via bacterial extracellular vesicles that cross the blood-brain barrier and activate TLR4/TLR8 signaling in the brain and trigeminal ganglion.

This study compares transcriptomic data across mice, rats, and humans to identify conserved and species-specific molecular mechanisms of Diabetic Retinopathy.

This study shows that renal fibrosis induced by injury promotes cyst formation and growth in adult ADPKD mice, and targeting EZH2 can reduce fibrosis and cyst growth.

This study measures blood flow velocity in the internal jugular vein under varying intrapulmonary pressure and gravitational conditions in healthy volunteers.

This study shows that deleting Pax2 and Pax8 in proximal tubules reduces acute kidney injury severity and prevents chronic disease by inducing protective gene expression similar to preconditioning.

This study investigates serum SCUBE-1 levels as a marker for diagnosing and monitoring subclinical atherosclerosis in obese and diabetic rats.

This study investigates the hepatic iron overload in Bmp6 knockout mice, showing age-related iron accumulation and subcellular Fpn localization changes.

HistoMIL simplifies training Multiple Instance Learning models on histopathology slides, achieving up to 85% AUROC for cancer gene prediction.

This study shows that endothelial SARS-CoV-2 infection does not significantly contribute to COVID-19-associated vascular pathology in mice.

This study identifies an interaction between obesity-elicited macrophages and CD9hi progenitors that drives adipose tissue fibrosis and dysfunction in mice and humans.

This study shows that simultaneous deletion of Pten and p53 in endometrial epithelial cells leads to epithelial to mesenchymal transition and the formation of uterine carcinosarcomas in vivo.