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This study shows that varying Pannexin 1 levels in smooth muscle cells affects sympathetic nerve-induced vasoconstriction and blood pressure in mice.

This study uses image-based phenotyping to predict wheat yield and protein content, showing moderate accuracy and insights into genotype-environment interactions.

This study develops a method to visualize sub-sarcomere structures using optimized super-resolution microscopy and VHH nanobodies, enabling precise protein localization analysis in skeletal muscle.

This study shows low molecular weight hyaluronan inhibits lung epithelial ion transport by activating the calcium-sensing receptor, with effects reversed by a CaSR inhibitor or high molecular weight hyaluronan.

This study shows that overexpressing cystathionine gamma lyase (CGL) enhances neovascularization in ischemic muscle through NAD-dependent mechanisms by improving endothelial cell migration.

This study uses high-throughput field phenotyping to show that wheat breeding since 1970 has altered phenology and temperature response in the stem elongation phase, aiding climate adaptation.

This study shows that muscle FOXO overexpression and endurance exercise protect skeletal and heart muscle from high-fat diet-induced defects in Drosophila by enhancing antioxidant pathways and lipid catabolism.

This study shows that 15 days of hindlimb unloading in rats reduces baroreflex sensitivity and heart rate variability, but does not cause structural changes in carotid arteries.

This study uses proteogenomics to identify age and sex-dependent gene expression and splicing changes in mouse hearts, revealing sexual dimorphism in cardiac aging and regulatory networks.

This study shows that loss of intra-islet glucagon receptor signaling impairs glucose tolerance and insulin pulsatility in mice, suggesting glucagonergic agents could restore insulin pulsatility in T2D.

This study investigates the role of astroglial ACBP in feeding responses to metabolic challenges and finds it is required for appropriate feeding during increased energy demand.

This study shows high-fructose diets impair brown adipose tissue glucose uptake in young men without affecting thermogenesis, gut microbiome, or body mass.

This study measures metabolic costs of walking and arm reaching in people with mild MS and controls, finding higher walking costs in MS but no reaching cost differences.

This study shows gain-of-function dynamin-2 mutations impair Ca2+-induced exocytosis in human myoblasts by reducing pHluorin signals and disrupting actin filament formation.

This study shows that cold acclimation in Drosophila melanogaster lowers the critical thermal minimum by reducing Na+/K+-ATPase sensitivity to temperature, without changing pump abundance.

This paper challenges the hyperbolic model of the power-duration relationship, showing that a power-law model better represents exercise performance and fatigue across different durations.

The paper investigates membrane retrieval and IRP replenishment mechanisms in chromaffin cells, finding dynamin-dependent and dynamin-independent pathways involving PKC.

This study investigates the mechanism by which fertilization activates PLC in Xenopus laevis eggs to trigger the fast block to polyspermy, finding no effect from inhibitors of PLCγ or Gq/11 pathways.

This study investigates whether enhancing natriuretic peptide signaling in skeletal muscle improves exercise performance in mice, finding no significant improvement in knockout mice.

This study investigates how intracellular Ca2+ affects the rundown rate of TMEM16A currents in excised patches by modulating PLC activity and PI(4,5)P2 levels.