R. Ghosh

Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation

This paper describes the structure and function of M.BceJIV, a DNA methyltransferase in Burkholderia cenocepacia, showing it binds two DNA sequences simultaneously for methylation.

A Fluorogenic-Based Assay to Measure Chaperone-Mediated Autophagic Activity in Cells and Tissues

The paper develops a fluorogenic assay to measure chaperone-mediated autophagy (CMA) activity in cells and tissues by using a KFERQ-AMC substrate and quantifying fluorescence release.

Molecular mechanisms and energetics of lipid droplet formation and directional budding

This study uses simulations to show lipid droplet (LD) formation and budding are governed by ER and LD tensions, with budding being energetically neutral and tension-independent.

Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells.

This study uses DNP-assisted NMR to show that α-synuclein adopts helical-rich conformations near the cell periphery in intact cells.

Biomechanical comparison of plate materials and designs for subcondylar fracture fixation: An in silico assessment

This study compares plate materials and designs for subcondylar fracture fixation using finite element analysis, finding that double mini plates and titanium alloys provide the best stability.

Single-tier point-of-care serodiagnosis of Lyme disease

This paper develops a single-tier point-of-care serodiagnostic test for Lyme disease using synthetic peptides and machine learning, achieving sensitivity and specificity comparable to traditional two-tier lab tests.

Membrane curvature sensing by model biomolecular condensates

This study uses simulations to show that biomolecular condensates can sense membrane curvature by localizing at curved regions, suggesting a general mechanism for curvature sensing in processes like endocytosis.

Temporal modification of H3K9/14ac and H3K4me3 histone marks mediates mechano-responsive gene expression during the accommodation process in poplar.

This study shows that histone modifications H3K9/14ac and H3K4me3 mediate mechano-responsive gene expression in poplar, with H3K4me3 playing a key role in desensitization and resensitization phases.

Effects of netarsudil-family Rho kinase inhibitors on human trabecular meshwork cell contractility and actin remodeling using a bioengineered ECM hydrogel

Chemical ecology of Himalayan eggplant variety's antixenosis: Identification of geraniol as an oviposition deterrent against the eggplant shoot and fruit borer

The paper identifies geraniol as an oviposition deterrent in the Himalayan eggplant variety RL22 against the shoot and fruit borer, reducing the need for harmful pesticides.

Essential Loop Dynamics Modulates Catalytic Activity in α-Chymotrypsin

This study investigates how essential loop dynamics in alpha-chymotrypsin affect its catalytic activity using optical spectroscopy and molecular dynamics simulations.

A Combined Spectroscopic and Molecular Modeling Study on Structure-Function-Dynamics under Chemical Modification: Alpha-Chymotrypsin with Formalin Preservative

This study examines how formalin modifies alpha-chymotrypsin's structure and function, showing reduced catalytic activity and altered substrate binding due to cross-linking.

In-Cell Sensitivity-Enhanced NMR of Intact Living Mammalian Cells

This study establishes conditions for dynamic nuclear polarization (DNP) assisted MAS NMR to detect proteins in viable mammalian cells at micromolar concentrations.

Late-in-life treadmill-training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts.

This study shows that treadmill training in old mice improves autophagy, protein aggregate clearance, and heart function.

Redox Buffering Capacity of Nanomaterials as an Index of ROS-based Therapeutics and Toxicity: A Preclinical Animal Study

This study evaluates the redox buffering capacity of nanomaterials to assess their therapeutic potential and toxicity in a preclinical animal model.

Development of Tribo-Electroceutical Fabrics for Potential Application in Self-sanitizing Personal Protective Equipment (PPE)

This paper develops tribo-electroceutical fabrics that generate hypochlorite ions to sanitize PPE surfaces, reducing microbial infection risk.

Nanoceutical Fabric Prevents COVID-19 Spread through Expelled Respiratory Droplets: A Combined Computational, Spectroscopic and Anti-microbial Study

The paper develops a nanoceutical cotton fabric with zinc oxide nanoflowers to prevent COVID-19 spread through respiratory droplets by trapping and denaturing SARS-CoV-2 spike proteins.

A Nanoceutical Agent for Chemoprevention of Bilirubin Encephalopathy

This paper reports on the development and testing of citrate-functionalized Mn3O4 nanoparticles for the prevention of bilirubin encephalopathy in a mouse model of neonatal hyperbilirubinemia.

VirION2: a short- and long-read sequencing and informatics workflow to study the genomic diversity of viruses in nature

VirION2 improves viral metagenomics by integrating short- and long-read sequencing, enhancing genome recovery and microdiversity detection in low-biomass samples.

Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival

This study shows that targeting the UPR components IRE1α and PERK can inhibit pancreatic neuroendocrine tumor growth by inducing apoptosis through reciprocal signaling.