Author

Y. Chao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cancer Biology· 2 Plant Biology· 2 Biochemistry· 1 Biophysics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:human· 5 Organism:bacteria (other)· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

S. Zhang· 3 shared C. Yang· 2 shared L. Li· 2 shared R. Sugimura· 2 shared S. L. Svensson· 2 shared X. Lin· 2 shared Y. Huang· 2 shared Y. Zhang· 2 shared

Activity by Year

2018-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCancer Biology

S. Zhang

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Author profile →

13 papers

Recent·Most cited

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

C. Yang, H. Qiu, S. L. Svensson, C. Ni, S. Gao, Z. Jia, H. Wen, L. Xie, W. Xu, Y. Qin, S. Lin, J. Wang, Y. Zhang, Y. Li, M. Jiang, , D. Falush

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

Nature Ecology & Evolution · Aug 27, 2025Peer-reviewedMicrobiology

Lipidic and senescent macrophages predict progression and response to combinatorial immunotherapy in triple-negative breast cancer

C. L. Chan, A. To, S. Zhang, J. W. H. Wong, Y. Huang, Y. Chao, R. Sugimura

bioRxiv · Jun 24, 2024 · PreprintCancer Biology

RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and virulence

K. Wu, X. Lin, Y. Lu, R. Dong, H. Jiang, S. L. Svensson, J. Zheng, N. Shen, A. Camilli, Y. Chao

This study identifies ArcZ as a small RNA inhibitor of capsular hypermucoviscosity and virulence in hypervirulent Klebsiella pneumoniae through RNA interactome profiling.

bioRxiv · Jun 23, 2024 · PreprintMicrobiology

Transport and inhibition mechanism for VMAT2-mediated synaptic loading of monoamines

Y. Wang, P. Zhang, Y. Chao, Z. Zhu, C. Yang, Z. Zhou, Y. Li, Y. Long, Y. Liu, D. Li, S. Wang, Q. Qu

This study presents cryo-EM structures of VMAT2 bound to substrates and inhibitors, revealing conformational changes and mechanisms of ligand recognition and inhibition.

bioRxiv · Oct 27, 2023 · PreprintBiophysics

Rof is a key regulator of Rho and transcription termination in bacteria

J. Zhang, S. Zhang, W. Zhou, X. Zhang, G. Li, L. Li, X. Lin, F. Liu, Y. Gao, Z. Chen, Y. Chao, C. Wang

This study reports the cryo-EM structure of the Rho-Rof antitermination complex and shows Rof inhibits Rho-dependent termination, essential for bacterial virulence.

bioRxiv · Sep 1, 2023 · PreprintMicrobiology

PD-L1 regulates inflammatory macrophage development from human pluripotent stem cells by maintaining interferon-gamma signal

H. Cao, Y. Xiang, S. Zhang, Y. Chao, J. Guo, J. W. K. Ho, Y. Huang, P. Liu, R. Sugimura

This study shows PD-L1 maintains IFN-gamma signaling in human pluripotent stem cell-derived macrophages, essential for their development and inflammatory function.

bioRxiv · Dec 14, 2022 · PreprintImmunology

Arabidopsis ORP2A positively regulates glucose signaling by interacting with AtRGS1 and promoting AtRGS1 degradation

Q. Yu, W. Zou, K. Liu, J. Sun, Y. Chao, M. Sun, Q. Zhang, X. Wang, X. Wang, L. Ge

bioRxiv · Nov 23, 2022 · PreprintPlant Biology

Protein kinase D promotes prostate cancer cell bone metastasis by positively regulating Runx2 in a MEK/ERK1/2-dependent manner

A. Roy, S. Prasad, Y. Chao, J. Zhao, Q. Wang

This study shows that PKD promotes prostate cancer bone metastasis by regulating Runx2 via MEK/ERK1/2 signaling, and inhibiting PKD reduces metastasis in mice.

bioRxiv · Apr 16, 2022 · PreprintCancer Biology

Gut microbiota-derived tryptamine impairs insulin sensitivity

L. Zhai, H. Xiao, C. Lin, Y. Y. Lam, H. L. X. Wong, M. Gong, G. Wu, Y. Deng, Z. Ning, C. Huang, Y. Zhang, M. Zhuang, Y. Chao, E. L. Zhang, L. Zhao, , Z.-x. Bian

This study identifies tryptamine, a gut microbiota-derived metabolite, as a contributor to insulin resistance in type 2 diabetes through TAAR1-ERK signaling.

bioRxiv · Mar 5, 2022 · PreprintMicrobiology

RNase E endonuclease activity and its inhibition by pseudoridine

M. S. Islam, K. J. Bandyra, Y. Chao, J. Vogel, B. F. Luisi

This study investigates RNase E's endonuclease activity, its inhibition by pseudouridine, and its interaction with partner proteins in the RNA degradosome.

bioRxiv · May 23, 2021 · PreprintBiochemistry

sPepFinder expedites genome-wide identification of small proteins in bacteria

L. Li, Y. Chao

sPepFinder identifies small proteins in bacteria using sequence features and machine learning, achieving high accuracy and discovering thousands of novel small ORFs.

bioRxiv · May 5, 2020 · PreprintMicrobiology

Comparative transcriptomics reveal that adaptive evolution in immune genes drives the local adaptation and speciation of schizothoracine fish

D. Qi, R. Wu, Y. Chao, M. Xia, Q. Chen, Z. Zheng

This study identifies immune-related genes under positive selection in schizothoracine fish, linking their adaptive evolution to speciation and local adaptation on the Qinghai-Tibetan Plateau.

bioRxiv · Jul 26, 2019 · PreprintEvolutionary Biology

Analysis of Transcripts and splice isoforms in Red Clover (Trifolium pratense L.) by single-molecule long-read sequencing

Y. Chao, J. Yuan, S. Li, S. Jia, L. Han, L. Xu

This study uses single-molecule long-read sequencing to analyze red clover transcriptome, identifying novel splice isoforms, alternative splicing events, and non-coding RNAs.

bioRxiv · May 25, 2018Plant Biology