D. Mitra

Redefining FLASH RT: the impact of mean dose rate and dose per pulse in the gastrointestinal tract

This study evaluates how varying radiation beam parameters affect gastrointestinal toxicity and tumor response in mice, finding that high dose per pulse and ultra-high dose rate independently reduce toxicity while maintaining tumor control.

An ab initio information-theoretic approach to proteins and protein-ligand interactions

The paper introduces a novel information-theoretic method to analyze protein conformational changes and their functional implications across different states.

Surface adhesion and membrane fluctuations influence the elastic modulus of extracellular vesicles

This study develops a method to accurately measure the elastic modulus of extracellular vesicles, showing that surface adhesion and membrane fluctuations significantly affect the results.

Measuring RBC deformability and its heterogeneity using a fast microfluidic device

The paper introduces a microfluidic device to measure RBC deformability and Young's modulus, showing stiffer RBCs deflect more and enabling sorting based on deformability.

Formation of clathrin-pits and ATP-independent cholesterol-dependent tubules initiates mechano-regulation on de-adhesion.

This study shows that during de-adhesion, cells use endocytosis to regulate membrane fluctuations, with dynamin-dependent and cholesterol-dependent ATP-independent mechanisms contributing.

Heavy-chain CDR3-engineered B cells facilitate in vivo evaluation of HIV-1 vaccine candidates

The paper evaluates HIV-1 vaccine candidates using HCDR3-engineered B cells, finding that SOSIP-TM mRNA-lipid nanoparticles induce stronger anti-apex responses than multimerized SOSIP proteins.

Decoding Sequence-Structure-Function-Evolution of basic Leucine Zippers of Aureochromes from Heterokont Algae

This study investigates the sequence, structure, and function of Aureochrome bZIP domains using computational and experimental methods, revealing unique features in DNA binding and evolutionary significance.

A Robust, Low-Cost Instrument for Real-time Colorimetric Isothermal Nucleic Acid Amplification

The paper describes the development of a low-cost instrument for real-time colorimetric isothermal nucleic acid amplification assays, demonstrating its performance and applications.

The degree of polymerization and sulfation patterns in heparan sulfate are critical determinants of cytomegalovirus entry into host cells

Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives

This study evaluates the antiviral activity of heparin and enoxaparin derivatives against SARS-CoV-2 by testing their ability to neutralize pseudotyped virus particles.

A fast microfluidic device to measure the deformability of red blood cells

This paper introduces a microfluidic device to measure red blood cell deformability, showing it can estimate elastic constants and sort cells based on deformability.

VHL Synthetic Lethality Signatures Uncovered by Genotype-specific CRISPR-Cas9 Screens

The paper uses CRISPR-Cas9 screens in isogenic ccRCC cell lines to identify synthetic lethal partners of VHL, revealing new therapeutic targets for renal cell carcinoma.

Dynamin is required for efficient cytomegalovirus maturation and envelopment

This study shows dynamin is required for efficient cytomegalovirus maturation and envelopment, but not for early infection stages.

Microtubule-associated protein IQ67 DOMAIN5 regulates interdigitation of leaf pavement cells in Arabidopsis thaliana

This study identifies IQD5 as a microtubule-associated protein regulating pavement cell shape in Arabidopsis by linking calcium signaling to interdigitation and asymmetric expansion.