Activation of the chemokine receptor CCR1 and preferential recruitment of Gαi suppress RSV replication: implications for developing novel RSV treatment strategies
J. Li, L. Xue, j. c. wang, A. Meng, J. Qiao, M. Li, X. Wang, L. Meng, J. Ning, X. Gao, W. Li, C. Ma, L. Wei
This study shows that CCR1 activation on respiratory epithelial cells suppresses RSV replication via Gi-mediated inhibition of STAT3 phosphorylation and HSP90 activity, independent of IFN-I.
bioRxiv · Mar 18, 2022 · PreprintMicrobiology