J. Ning

Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization

The paper investigates why C. difficile colonization leads to varying disease outcomes by studying microbiota-humanized mice and identifying commensals that mitigate virulence.

LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironment

This study shows that LHPP promotes TNBC growth and metastasis by altering the tumor microenvironment and chemokine signaling.

Activation of the chemokine receptor CCR1 and preferential recruitment of Gαi suppress RSV replication: implications for developing novel RSV treatment strategies

This study shows that CCR1 activation on respiratory epithelial cells suppresses RSV replication via Gi-mediated inhibition of STAT3 phosphorylation and HSP90 activity, independent of IFN-I.

Genomic insights into the phylogeny and biomass-degrading enzymes of rumen ciliates

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

Therapeutic activation of virus-specific resident memory T cells within the glioblastoma microenvironment

This study shows that virus-specific memory T cells reside in glioblastoma and can be reactivated to improve survival in a mouse model.

PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.

CryoET structures of immature HIV Gag reveal a complete six-helix bundle and stabilizing small molecules distinct from IP6

The paper determines the structure of the HIV Gag six-helix bundle using cryoET and identifies small molecules stabilizing the immature lattice.

exosome-LncPICALM-AU1 regulates endothelial-mesenchymal transition in hepatopulmonary syndrome

This study identifies exosomal lncRNA PICALM-AU1 from cholangiocytes as a key regulator of endothelial-mesenchymal transition in hepatopulmonary syndrome, with potential as a biomarker and therapeutic target.

Single-cell Characterization of Acute Myeloid Leukemia and its Microenvironment Following PD-1 Blockade Based Therapy

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.

Cytoplasmic CPSF6 regulates HIV-1 capsid trafficking and infection in a cyclophilin A-dependent manner

The paper shows CPSF6 and CypA interact to regulate HIV-1 capsid trafficking and infection by affecting capsid-CPSF6 complex formation and stability.

Serial cryoFIB/SEM reveals profound cytoarchitectural disruptions caused by a pathogenic mutation in Leigh syndrome patient cells

The paper uses serial cryoFIB/SEM to show cytoarchitectural disruptions in Leigh syndrome patient fibroblasts due to a USMG5 mutation.

A mouse SWATH-MS reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts

The paper develops a mouse SWATH-MS spectral library and a deconvolution method to analyze proteomic changes in human tumor xenografts, revealing host-tumor interactions.