A. Ojha

Simulation-Driven Design of Stabilized SARS-CoV-2 Spike S2 Immunogens

This study designs stabilized SARS-CoV-2 S2 immunogens using simulation-driven approaches, showing improved stability and immunogenicity.

Development of Gemcitabine-Modified miRNA Mimics as Cancer Therapeutics for Pancreatic Ductal Adenocarcinoma

Yuen and Hwang et al. developed Gem-modified miRNA mimics that show enhanced efficacy in inhibiting PDAC cell growth and tumor progression with reduced toxicity.

Reduced blood to brain glucose transport as the cause for hyperglycemia in a model 2 resolves multiple anomalies in type 2 diabetes

The paper proposes a model where reduced blood-to-brain glucose transport explains hyperglycemia in type 2 diabetes and resolves multiple anomalies not addressed by traditional insulin resistance models.

The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity

The paper compares the D614G mutation in SARS-CoV-2 spike protein, finding it reduces S1 shedding and increases infectivity without affecting ACE2 binding or neutralization.

An engineered receptor-binding domain improves the immunogenicity of multivalent SARS-CoV-2 vaccines

This paper shows that an engineered RBD with glycosylation sites improves immunogenicity and expression efficiency in SARS-CoV-2 vaccines.

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2

This paper shows hydroxychloroquine inhibits SARS-CoV-2 entry via cathepsin L but not TMPRSS2, and that combining it with a TMPRSS2 inhibitor enhances antiviral effects.

The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement

This study shows that immunization with SARS-CoV-2 RBD elicits potent neutralizing antibodies without antibody-dependent enhancement in rodents.