Author

H. Choe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1

Frequent Co-Authors

M. Farzan· 6 shared H. Mou· 5 shared L. Zhang· 5 shared A. Ojha· 4 shared B. D. Quinlan· 2 shared B. Quinlan· 2 shared G. Zhong· 2 shared M. S. Parcells· 2 shared

Activity by Year

2020-2022 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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6 shared papersMicrobiology

M. Farzan

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Heavy-chain CDR3-engineered B cells facilitate in vivo evaluation of HIV-1 vaccine candidates

W. He, T. Ou, N. Skamangas, C. Bailey, N. Bronkema, Y. Guo, Y. Yin, V. Kobzarenko, X. Zhang, A. Pan, X. Liu, A. Allwardt, D. Mitra, B. Quinlan, R. Sanders, , M. Farzan

The paper evaluates HIV-1 vaccine candidates using HCDR3-engineered B cells, finding that SOSIP-TM mRNA-lipid nanoparticles induce stronger anti-apex responses than multimerized SOSIP proteins.

bioRxiv · Nov 7, 2022 · PreprintImmunology

The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity

L. Zhang, C. B. Jackson, H. Mou, A. Ojha, E. S. Rangarajan, T. Izard, M. Farzan, H. Choe

The paper compares the D614G mutation in SARS-CoV-2 spike protein, finding it reduces S1 shedding and increases infectivity without affecting ACE2 binding or neutralization.

Nature Communications · Nov 26, 2020Peer-reviewedMicrobiology

An engineered receptor-binding domain improves the immunogenicity of multivalent SARS-CoV-2 vaccines

B. D. Quinlan, W. Li, H. Mou, L. Zhang, J. Chang, S. Peng, A. Ojha, R. Tavora, M. S. Parcells, G. G. Luo, W. Li, G. Zhong, H. Choe, M. Farzan

This paper shows that an engineered RBD with glycosylation sites improves immunogenicity and expression efficiency in SARS-CoV-2 vaccines.

bioRxiv · Nov 18, 2020Microbiology

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2

T. Ou, H. Mou, L. Zhang, A. Ojha, H. Choe, M. Farzan

This paper shows hydroxychloroquine inhibits SARS-CoV-2 entry via cathepsin L but not TMPRSS2, and that combining it with a TMPRSS2 inhibitor enhances antiviral effects.

bioRxiv · Jul 22, 2020Microbiology

Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2

H. Mou, B. Quinlan, H. Peng, Y. Guo, S. Peng, L. Zhang, M. Davis-Gardner, M. Gardner, Z. X. Voo, C. C. Bailey, M. Alpert, C. Rader, H. Choe, M. Farzan

bioRxiv · Jun 29, 2020Microbiology

Mitigation of radiation damage in macromolecules via tunable ultrafast stroboscopic TEM

H. Choe, I. Ponomarev, E. Montgomery, J. W. Lau, Y. Zhu, Y. Zhao, A. Liu, A. Kanareykin, C. Jing

This paper demonstrates a tunable ultrafast stroboscopic TEM system that reduces radiation damage in macromolecules by increasing critical dose at room temperature.

bioRxiv · May 15, 2020 · PreprintBiophysics

The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement

B. D. Quinlan, H. Mou, L. Zhang, Y. Gao, W. He, A. Ojha, M. S. Parcells, G. Luo, W. Li, G. Zhong, H. Choe, M. Farzan

This study shows that immunization with SARS-CoV-2 RBD elicits potent neutralizing antibodies without antibody-dependent enhancement in rodents.

bioRxiv · Apr 10, 2020 · PreprintMicrobiology