G. Luo

Construction and application of a technical platform for determining cell cycle- and autophagy-associated cellular accumulation of lipid-based nanoparticles

This study constructs a technical platform to investigate cell cycle- and autophagy-related nanoparticle accumulation, revealing distinct accumulation patterns in specific cell cycle phases.

Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions

This paper introduces Blocker-SELEX, a structure-guided method to design inhibitory aptamers that disrupt transcription factor interactions, demonstrating efficacy against SCAF4/SCAF8-RNAP2 and WDR5-MYC complexes.

WTAP, transcriptionally regulated by p65, promotes inflammation through m6A modification and phase separation

This study identifies WTAP as a p65-regulated m6A writer that promotes inflammation via phase separation and m6A modification, offering a therapeutic target for hyperinflammation.

High-throughput generic single-entity sequencing using droplet microfluidics

This paper introduces GSE-Seq, a high-throughput platform for single-entity sequencing that enables long-read profiling of dsDNA and ssDNA from viruses and bacteria, revealing previously overlooked dark matter and phage-host interactions.

A core NRF2 gene set defined through comprehensive transcriptomic analysis predicts selective drug resistance and poor multi-cancer prognosis

The paper defines a core NRF2 gene set from transcriptomic data that predicts drug resistance and poor cancer prognosis across multiple cancer types.

NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinoma

The paper identifies NDC80 as a predictor of ccRCC progression and shows that NDC80-high tumors are sensitive to mitotic kinase inhibitors.

Polyethylene glycol (PEG)-associated immune responses triggered by clinically relevant lipid nanoparticles in rats

This study shows that LNP-based vaccines induce time- and dose-dependent anti-PEG antibodies in rats, with immune memory and accelerated blood clearance upon re-injection.

Effects of protoscoleces excretory-secretory products of Echinococcus granulosus on hepatocyte growth, function, and glucose metabolism

This study investigates how excretory-secretory products from Echinococcus granulosus protoscoleces affect mouse hepatocyte growth, function, and glucose metabolism, finding inhibition of proliferation, promotion of apoptosis, and disruption of metabolic pathways.

Development of Equine Polyclonal Antibodies as a Broad-Spectrum Therapy Against SARS-CoV-2 Variants

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

Assessment of Human Renal Transporter Based Drug-Drug Interactions Using Proximal Tubule Kidney-Chip

This study develops a human Proximal Tubule Kidney-Chip to assess renal transporter-based drug-drug interactions and demonstrates its ability to predict clinical outcomes and clearance values.

Regulation of osteoblast autophagy based on PI3K/AKT/mTOR signaling pathway study on the effect of β-ecdysterone on fracture healing

This study investigates how β-ecdysterone affects fracture healing by modulating autophagy via the PI3K/AKT/mTOR pathway in osteoblasts.

Taxonomic description and genome sequence of Christensenella intestinihominis sp. nov., a novel cholesterol-lowering bacterium isolated from human gut

This paper describes a new bacterial species, Christensenella intestinihominis, isolated from the human gut, and reports its cholesterol-lowering ability and exopolysaccharide production.

Butyribacter intestini gen. nov., sp. nov., a butyric acid-producing bacterium of the family Lachnospiraceae isolated from the human faeces, and reclassification of Acetivibrio ethanolgignens as Acetanaerobacter ethanolgignens gen. nov., comb. nov.

The paper describes the isolation and characterization of a new butyric acid-producing bacterium from human feces, and reclassifies another species within the same family.

Mass Spectrometric Characterization of Narcolepsy-Associated Pandemic 2009 Influenza Vaccines.

This study uses mass spectrometry to compare mutations in Pandemrix and Arepanrix vaccines, finding differences in protein modifications that may explain varying narcolepsy risks.

The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement

This study shows that immunization with SARS-CoV-2 RBD elicits potent neutralizing antibodies without antibody-dependent enhancement in rodents.

The anaerobic digestion microbiome: a collection of 1600 metagenome-assembled genomes shows high species diversity related to methane production

This study compiles 1,635 metagenome-assembled genomes from 134 biogas reactor datasets to explore microbial diversity and functional traits in anaerobic digestion.

Autoimmunity to hypocretin and molecular mimicry to flu antigens in Type 1 narcolepsy

This study identifies autoimmunity to hypocretin and molecular mimicry with flu antigens in Type 1 narcolepsy, showing genetic modulation of T cell responses.