Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination
J. Clark, I. Hoxie, D. Adelsberg, I. Sapse, R. Andreata-Santos, J. Yong, F. Amanat, J. Tcheou, A. Raskin, G. Singh, I. Gonzalez-Dominguez, J. Edgar, S. Bournazos, W. Sun, J. M. Carreno, , F. Krammer
This study identifies non-neutralizing antibodies from vaccinated individuals that protect against SARS-CoV-2 in animal models, highlighting their role through Fc-mediated effector functions and conserved epitope binding.
bioRxiv · Feb 28, 2024Immunology