Author

R. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

Y. Fu· 3 shared A. Singh· 2 shared B. Lee· 2 shared D. Bresson· 2 shared D. Tortorella· 2 shared H. Ji· 2 shared H. Zhou· 2 shared J. A. Duty· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

Y. Fu

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype

F. McLean, B. R. Omondi, N. Diallo, S. Otoboh, C. Kifude, A. Abdi, R. Lim, T. Otto, A. Ghumra, A. Rowe

The paper identifies novel PfEMP1 variants associated with rosetting in Plasmodium falciparum, expanding the known types of PfEMP1 that mediate this phenotype.

bioRxiv · Jul 22, 2024 · PreprintMicrobiology

Simultaneous detection of pathogens and antimicrobial resistance genes with the open source, cloud-based, CZ ID pipeline

D. Lu, K. L. Kalantar, V. T. Chu, A. L. Glascock, E. S. Guerrero, N. Bernick, X. Butcher, K. Ewing, E. Fahsbender, O. Holmes, E. Hoops, A. E. Jones, R. Lim, S. McCanny, L. Reynoso, , C. R. Langelier

The paper develops an open-source, cloud-based tool for detecting pathogens and antimicrobial resistance genes in metagenomic and whole-genome sequencing data, demonstrating its application across clinical and environmental studies.

bioRxiv · Apr 12, 2024 · PreprintMicrobiology

Integrative mapping reveals molecular features underlying the mechanism of nucleocytoplasmic transport

B. Raveh, R. Eliasian, S. Rashkovits, D. Russel, R. Hayama, S. Sparks, D. Singh, R. Lim, E. Villa, M. P. Rout, D. Cowburn, A. Sali

The paper constructs an integrative Brownian dynamics model of nucleocytoplasmic transport, revealing how FG repeat proteins and nuclear transport receptors mediate selective transport through NPCs.

bioRxiv · Dec 31, 2023 · PreprintCell Biology

Acetyl-CoA carboxylase inhibition increases RPE cell fatty acid oxidation and limits apolipoprotein efflux

D. T. Hass, K. Pandey, A. L. Engel, N. Horton, B. M. Robbings, R. Lim, M. Sadilek, Q. Zhang, G. A. Autterson, J. M. Miller, J. R. Chao, J. B. Hurley

This study shows that inhibiting acetyl-CoA carboxylase with Firsocostat increases fatty acid oxidation and reduces lipid deposits in RPE cells, potentially limiting drusen accumulation in AMD.

bioRxiv · Nov 7, 2023 · PreprintBiochemistry

An in vitro experimental pipeline to characterize the binding specificity of SARS-CoV-2 neutralizing antibodies

K. E. Atanasoff, L. Brambilla, D. C. Adelsberg, S. S. Kowdle, C. S. Stevens, C.-t. Hung, Y. Fu, R. Lim, L. Tran, R. Allen, J. A. Duty, G. Bajic, B. Lee, D. Tortorella

This paper characterizes the binding specificity and epitope of a broadly neutralizing anti-SARS-CoV-2 Spike RBD antibody using mAb-resistant virions and cryo-EM structural analysis.

bioRxiv · Apr 20, 2023 · PreprintMicrobiology

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

J. A. Duty, T. A. Kraus, H. Zhou, Y. Zhang, N. Shaabani, S. Yildiz, N. Du, A. Singh, L. Miorin, D. Li, K. Stegman, S. I. Ophir, X. Cao, K. Atanasoff, R. Lim, , R. Allen

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology

Generalized Michaelis-Menten rate law with time-varying molecular concentrations

R. Lim, T. L. P. Martin, J. Chae, W. Kim, C.-M. Ghim, P.-J. Kim

This paper generalizes the Michaelis-Menten rate law to account for time-varying molecular concentrations by introducing the effective time-delay scheme (ETS).

bioRxiv · Jan 7, 2022Biochemistry

Protective Effects of STI-2020 Antibody Delivered Post-Infection by the Intranasal or Intravenous Route in a Syrian Golden Hamster COVID-19 Model

Y. Fu, J. Maruyama, A. Singh, R. Lim, A. Ledesma, D. Lee, L. Rivero-Nava, J. Ko, I. Rivera, R. A. Sattler, J. T. Manning, L. Kerwin, H. Zhou, M. Brunswick, D. Bresson, , R. D. Allen

This study evaluates the efficacy of STI-2020 antibody delivered post-infection via intranasal or intravenous routes in a hamster model of COVID-19, showing reduced disease severity and duration.

bioRxiv · Oct 28, 2020 · PreprintMicrobiology