Q. Zeng

Dynamic Modeling of Antibody Repertoire Reshaping in Response to Viral Infections

This study uses mathematical modeling to show that viral infections reshape the antibody repertoire through the proliferation of high-affinity antibody pools and contraction of low-affinity pools, with self-antigens maintaining antibody persistence.

Single-nucleus Multiomic Analyses Identifies Gene Regulatory Dynamics of Phenotypic Modulation in Human Aneurysmal Aortic Root

This study uses single-nucleus multiomic and spatial transcriptomic data to identify gene regulatory dynamics and key regulators in human aortic root tissue under healthy and Marfan syndrome conditions.

Mathematical Modelling Indicates Th-cell Targeted Antibody-Dependent Cellular Cytotoxic Is a Crucial Obstacle Hurdling HIV Vaccine Development

This paper uses mathematical modeling to show that ADCC targeting Th cells hinders HIV vaccine development by damaging immune responses and reducing vaccine effectiveness.

Diversity of Bathyarchaeia viruses in metagenomes and virus-encoded CRISPR system components

The paper identifies 56 metagenome-assembled genomes of Bathyarchaeia viruses and describes their CRISPR system components, revealing potential counter-defense mechanisms.

Next-generation anti-PD-L1/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity

This study introduces a next-generation immunocytokine, LH05, which shows improved antitumor effects in cold tumors with reduced toxicity compared to wild-type anti-PD-L1/IL-15.

The TOR signaling pathway regulates vegetative development, aflatoxin biosynthesis, and pathogenicity in Aspergillus flavus

This study identifies and characterizes nine genes in the TOR signaling pathway of A. flavus, revealing their roles in growth, aflatoxin biosynthesis, and pathogenicity.

Impact of inter-species interactions between flower microbiota commensals and a floral pathogen on disease incidence and pathogen activity

The paper investigates how interactions between flower microbiota commensals and a floral pathogen affect disease incidence and pathogen activity through field and in vitro experiments.

Genetic basis of expression and splicing underlying spike architecture in wheat (Triticum aestivum L.)

This study identifies eQTLs and sQTLs associated with spike architecture in wheat, revealing genetic factors that regulate gene expression and splicing related to yield traits.

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

The paper identifies adaptive pathways in metabolic liver disease by selecting somatically mutated clones in mice and humans, finding mutations that ameliorate lipotoxicity and promote clonal expansion.

Modification of social cheating facilitates the stabilization and chronic infection of polymorphic Pseudomonas aeruginosa population

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

Dominant Role of Stochastic Processes in Soil Fungal Communities in Pioneer Forests at a Regional Scale

This study shows that stochastic processes dominate soil fungal community assembly in Populus davidiana forests, with elevation having a greater impact than seasonality.

The deacetylase dependent and independent role of HDAC3 in cardiomyopathy

This study investigates the deacetylase-dependent and independent roles of HDAC3 in cardiomyopathy using Drosophila, finding it maintains cardiac contractility and prevents Pericardin deposition independently of its deacetylase activity, but regulates triglyceride homeostasis through this activity.

Calpain-2 mediates SARS-CoV-2 entry and represents a therapeutic target

This study identifies calpain-2 as a host factor facilitating SARS-CoV-2 entry and shows calpain inhibitors inhibit viral infection through an Mpro-independent pathway.

Type 17 Follicular Helper T (Tfh17) Cells are Superior for Memory Maintenance

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

Distinct Single-cell Immune Ecosystems Distinguish True and De Novo HBV-related Hepatocellular Carcinoma Recurrences

This study identifies distinct immune ecosystems in true and de novo HBV-related HCC recurrences using single-cell and bulk RNA-sequencing, revealing differences in T cell phenotypes and immune interactions that may inform immunotherapy strategies.

Immunological findings in a group of individuals who were non-responders to standard two-dose SARS-CoV-2 vaccines

The paper compares immunological characteristics of SARS-CoV-2 vaccine non-responders aged 18-59 and 60+ to identify factors associated with seroconversion and recommend booster vaccinations.

Profiling the size-dependent heterogeneity of membrane proteins in a mixed population of small extracellular vesicle for potential cancer diagnosis

This study profiles size-dependent membrane protein heterogeneity in small EVs to improve cancer diagnosis accuracy using a novel single EV enumeration approach.

SARS-CoV-2 Omicron BA.1 variant infection of human colon epithelial cells

This study investigates the infection of human colon epithelial cells by the SARS-CoV-2 Omicron BA.1 variant, finding it infects similarly or less effectively than the ancestral strain and Delta variant.

More or less deadly? A mathematical model that predicts SARS-CoV-2 evolutionary direction.

This paper develops a mathematical model to predict SARS-CoV-2 evolutionary trends, finding that virulence may decrease while transmissibility increases, with virulence remaining stable.

Th1/17 Cells Infiltrate Murine Cytomegalovirus-Infected Renal Allografts via Virus-Induced CCL20 and Promote Th1 Cells through IL-17A.

This study shows CMV infection increases Th17 cells in renal grafts via CCL20, which correlates with Th1 cells and reduces Tregs, and IL-17A inhibition lowers Th17 cells without affecting antiviral Th1 cells.

Integration of the cyanophage-encoded phosphate binding protein into the cyanobacterial phosphate uptake system

This study shows that cyanophage PstS enhances host phosphate uptake and forms a chimeric ABC transporter with host proteins.

Rotavirus NSP1 contributes to intestinal viral replication, pathogenesis, and transmission

This study shows that NSP1 is essential for murine rotavirus replication, pathogenesis, and transmission in vivo, even though it is not required for replication in cell culture.

Gut microbiome couples gut and brain during calorie restriction in treating obesity

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

Snowball Earths, population bottlenecks, and Prochlorococcus evolution

This study links Prochlorococcus genome reduction to the Neoproterozoic Snowball Earth climate event, showing how extreme conditions drove metabolic adaptations.

JIB-04 has broad-spectrum antiviral activity and inhibits SARS-CoV-2 replication and coronavirus pathogenesis

The paper identifies JIB-04 as a broad-spectrum antiviral that inhibits SARS-CoV-2 replication and coronavirus pathogenesis in vitro and in vivo.

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

The paper identifies CH25H and its product 25HC as inhibitors of SARS-CoV-2 replication by blocking membrane fusion.

Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2.

This study develops two neutralization assays for SARS-CoV-2 using VSV and a clinical isolate, showing high concordance between monoclonal, polyclonal antibodies, and ACE2-Fc in neutralizing activity.

TMPRSS2 and TMPRSS4 mediate SARS-CoV-2 infection of human small intestinal enterocytes

This study shows SARS-CoV-2 infects human intestinal enterocytes via TMPRSS2 and TMPRSS4, but viral particles in stool are inactivated, suggesting limited fecal-oral transmission.

Local intracerebral Inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo.

The paper develops a novel immunocompetent GBM model to test the effect of IRE1 inhibition on treatment efficacy in vivo.

Temporal and spatial dynamics in the apple flower microbiome in the presence of the phytopathogen Erwinia amylovora

The paper examines the temporal and spatial dynamics of the apple flower microbiome under Erwinia amylovora infection, showing that pathogen load does not always predict disease symptoms.