Y. Dang

Pre-cancerous Niche Remodelling Dictates Nascent Tumour Survival

The paper shows that pre-cancerous niche remodeling by early tumour cells determines nascent tumour survival in mice.

Epigenetic insights into GABAergic development in Dravet Syndrome iPSC and therapeutic implications

This study investigates epigenetic changes in GABAergic development using DS iPSCs and shows that VPA can rescue some chromatin abnormalities.

Von Willebrand Factor Synergizes with Tumor-Derived Extracellular Vesicles to Promote Gastric Cancer Metastasis

This study shows that von Willebrand factor (VWF) and gastric cancer-derived extracellular vesicles (gcEVs) work together to promote metastasis by disrupting endothelial integrity and facilitating cancer cell migration.

Self-propagating wave drives noncanonical antidurotaxis of skull bones in vivo

The paper identifies a self-propagating motion mechanism in skull bone morphogenesis driven by mechanical feedback between stiffness and cell fate, termed noncanonical antidurotaxis.

Molecular mechanism of substrate recognition by folate transporter SLC19A1

This study determines the cryo-EM structure of SLC19A1 and identifies key residues and coupled substrates for folate recognition.

Life-course social disparities in body mass index trajectories across adulthood: cohort study evidence from China Health and Nutrition Survey

This study examines how socioeconomic status across the life course affects BMI trajectories and obesity risk in China using longitudinal data from the China Health and Nutrition Survey.

Transcriptomic analysis reveals hub genes and pathways in response to acetic acid stress in Kluyveromyces marxianus during high-temperature ethanol fermentation

This study identifies differentially expressed genes and pathways in Kluyveromyces marxianus under acetic acid stress during high-temperature ethanol fermentation, revealing effects on protein metabolism and ethanol production.

Sustained Oxygenation Accelerates Diabetic Wound Healing by Simultaneously Promoting Epithelialization and Angiogenesis, and Decreasing Tissue Inflammation

This study shows sustained oxygenation improves diabetic wound healing by enhancing epithelialization, angiogenesis, and reducing inflammation without drugs.

Ripasudil in a model of pigmentary glaucoma

This study evaluates Ripasudil's effects on pigmentary glaucoma in a porcine model, showing reduced trabecular meshwork stress fibers, restored phagocytosis, and normalized intraocular pressure.

Conserved Roles of C. elegans and Human MANFs in Sulfatide Binding and Cytoprotection

This study identifies C. elegans MANF orthologue, shows it binds sulfatide, and demonstrates sulfatide-dependent cytoprotection in both worms and mammalian cells.

Intraocular pressure elevation precedes a phagocytosis decline in a model of pigmentary glaucoma

This study shows that intraocular pressure elevation occurs before phagocytosis decline in a porcine model of pigmentary glaucoma, indicating separate mechanisms for these phenomena.

A porcine ex vivo model of pigmentary glaucoma

This study develops a porcine ex vivo model of pigmentary glaucoma, showing intraocular hypertension, pigment accumulation, and impaired phagocytosis in trabecular meshwork cells, with RhoA identified as a key regulator.