Author

B. Holzer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Organism:plant (other)· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:rat· 1

Frequent Co-Authors

E. Tchilian· 4 shared A. McNee· 2 shared B. Clark· 2 shared E. Bessell· 2 shared F. J. Salguero· 2 shared P. Beverley· 2 shared P. Rijal· 2 shared A. Livesey· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersImmunology

E. Tchilian

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

B. Holzer, P. Rijal, A. McNee, B. Paudyal, B. Clark, T. Manjegowda, F. J. Salguero, E. Bessell, J. C. Schwartz, K. Moffat, M. Pedrera, S. P. Graham, M. B.-D. Placido, R. M. La Ragione, W. Mwangi, , E. Tchilian

This study generates pig-specific monoclonal antibodies against H1N1pdm09 influenza virus that target human-like HA epitopes and reduce disease severity in pigs.

bioRxiv · Jul 21, 2020Immunology

Establishment of a pig influenza challenge model for evaluation of monoclonal antibody delivery platforms

A. McNee, T. Smith, B. Holzer, C. Becky, E. Bessell, G. Guibinga, H. Brown, K. Schultheis, P. Fisher, S. Ramos, A. Nunez, M. Bernard, V. Martini, T. Chrun, Y. Xiao, , E. Tchilian

This study establishes a pig influenza model to evaluate monoclonal antibody efficacy against H1N1, showing dose-dependent reduction in viral load and lung pathology.

bioRxiv · Mar 12, 2020Immunology

An alternative AUG codon in segment 5 of the 2009 pandemic influenza A virus is a swine-derived virulence motif

H. M. Wise, E. Gaunt, J. Ping, B. Holzer, S. Jasim, S. J. Lycett, L. Murphy, A. Livesey, R. Brown, N. Smith, S. Morgan, B. Clark, K. Kudryavtseva, P. M. Beard, J. Nguyen-Van-Tam, , P. Digard

The paper identifies an alternative AUG codon in the 2009 pandemic influenza A virus as a virulence factor contributing to pathogenicity in swine and humans.

bioRxiv · Sep 4, 2019 · PreprintMicrobiology

Highly mutated memory cells drive an inefficient secondary antibody response to a variant protein

R. K. Tennant, B. Holzer, J. Love, E. Tchilian, H. N. White

The paper shows that highly mutated memory B-cells can hinder secondary antibody responses to antigenic variants, even with adjuvant, compared to primary responses.

bioRxiv · Oct 8, 2018 · PreprintImmunology