K. Moffat

Single-cell analysis reveals lasting immunological consequences of influenza infection and respiratory immunisation in the pig lung

This study uses single-cell RNA sequencing and flow cytometry to analyze immunological changes in pig lungs after influenza infection or vaccination, revealing lasting effects on immune cell populations and function.

The mechanical arthropod vector Stomoxys calcitrans influences the outcome of lumpy skin disease virus infection in cattle

This study investigates how the mechanical transmission of lumpy skin disease virus (LSDV) by the stable fly Stomoxys calcitrans affects disease progression in cattle, finding that saliva and bite trauma accelerate disease kinetics.

The immune response to lumpy skin disease virus in cattle is influenced by inoculation route

This study compares immune responses in cattle inoculated with LSDV via needle or arthropod vectors, finding differences in clinical disease development and immune markers like IgM and IFN-γ.

Optimized Multicolour Immunofluorescence Panel for Cattle B Cell Phenotyping by an 8-Colour, 10-Parameter Panel

This paper optimizes an 8-color, 10-parameter immunofluorescence panel to identify five functionally distinct B cell subsets in cattle PBMCs.

Role of African swine fever virus (ASFV) proteins EP153R and EP402R in reducing viral persistence and virulence from attenuated BeninΔDP148R

This study investigates the role of ASFV proteins EP153R and EP402R in viral persistence and virulence by deleting them from an attenuated virus, showing that EP402R deletion reduces persistence while EP153R deletion alone has limited effect.

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

This study develops a vaccine candidate using SpyCatcher technology to display the SARS-CoV-2 RBD, showing strong neutralizing antibody responses in mice and pigs.

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

This study generates pig-specific monoclonal antibodies against H1N1pdm09 influenza virus that target human-like HA epitopes and reduce disease severity in pigs.

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

This study evaluates the immunogenicity of single and booster doses of the ChAdOx1 nCoV-19 vaccine in mice and pigs, finding that a booster significantly enhances antibody responses, especially in pigs.

The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser

This study captures the structural changes in bacterial phytochrome proteins after light exposure using femtosecond X-ray crystallography, revealing key molecular movements involved in the photoresponse.