Author

A. McNee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:plant (other)· 8 Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:flow cytometry· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

E. Tchilian· 8 shared B. Paudyal· 6 shared V. Martini· 6 shared P. Beverley· 5 shared A. Townsend· 4 shared M. Edmans· 4 shared P. Rijal· 4 shared A. Nunez· 3 shared

Activity by Year

2020-2021 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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8 shared papersImmunology

E. Tchilian

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8 papers

Recent·Most cited

Low dose pig anti-influenza virus monoclonal antibodies reduce lung pathology but do not prevent virus shedding

B. Paudyal, A. McNee, P. Rijal, B. V. Carr, A. Nunez, J. W. McCauley, R. S. Daniels, A. R. Townsend, J. A. Hammond, E. Tchilian

This study shows that high-dose pig monoclonal antibodies reduce lung pathology and virus load but not nasal shedding, suggesting lower doses may suffice for disease severity reduction.

bioRxiv · Oct 8, 2021Immunology

Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells.

V. Martini, M. Edmans, S. Gubbins, S. Jayaraman, B. Paudyal, S. Morgan, A. McNee, T. Morin, P. Rijal, W. Gerner, A. K. Sewell, R. Inoue, M. Bailey, T. Connelley, B. Charleston, , E. Tchilian

The paper identifies and characterizes influenza NP-specific CD8 T cells in porcine tissues, showing their persistence and gene expression changes in the lung.

bioRxiv · Aug 23, 2021Immunology

Simultaneous infection with porcine reproductive and respiratory syndrome and influenza viruses abrogates clinical protection induced by live attenuated porcine reproductive and respiratory syndrome vaccination

T. Chrun, E. A. Maze, E. Vatzia, V. Martini, B. Paudyal, M. Edmans, A. Mcnee, T. Manjegowda, F. J. Salguero, N. Wanasen, S. Koonpaew, S. P. Graham, E. Tchilian

This study shows that co-infection with PRRSV-2 and H3N2 virus reduces the protective effect of PRRS MLV vaccination against clinical disease.

bioRxiv · Aug 12, 2021Immunology

Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in outbred and inbred Babraham pigs

M. Edmans, A. Mcnee, E. Porter, E. Vatzia, B. Paudyal, V. Martini, S. Gubbins, O. Francis, R. Harley, A. Thomas, R. Burt, S. Morgan, A. Fuller, A. Sewell, B. Charleston, , E. Tchilian

This study compares T cell and antibody responses to H1N1pdm09 infection in inbred and outbred pigs, showing similar immune responses despite differences in genetic background.

bioRxiv · Oct 28, 2020Immunology

Simultaneous aerosol and intra-muscular immunization with influenza vaccine induces powerful protective local T cell and systemic Ab immune responses in pigs

V. Martini, B. Paudyal, T. Chrun, A. McNee, M. Edmans, E. Maze, B. Clark, A. Nunez, G. Dolton, A. Sewell, P. Beverley, R. MacLoughlin, A. Townsend, E. Tchilian

This study evaluates simultaneous aerosol and intramuscular influenza vaccination in pigs, finding that combined immunization induces both strong antibody and local T cell responses, leading to better virus control.

bioRxiv · Sep 10, 2020Immunology

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

B. Holzer, P. Rijal, A. McNee, B. Paudyal, B. Clark, T. Manjegowda, F. J. Salguero, E. Bessell, J. C. Schwartz, K. Moffat, M. Pedrera, S. P. Graham, M. B.-D. Placido, R. M. La Ragione, W. Mwangi, , E. Tchilian

This study generates pig-specific monoclonal antibodies against H1N1pdm09 influenza virus that target human-like HA epitopes and reduce disease severity in pigs.

bioRxiv · Jul 21, 2020Immunology

Distribution of droplets and immune responses after aerosol and intra-nasal delivery of influenza virus to the respiratory tract of pigs

V. Martini, M. Hinchcliffe, E. Blackshaw, M. Joyce, A. McNee, P. Beverley, A. Townsend, R. MacLoughlin, E. Tchilian

This study compares droplet distribution and immune responses from different delivery methods of influenza virus in pigs, finding MAD delivers high lung dose with systemic immune activation.

bioRxiv · Jun 4, 2020Immunology

Establishment of a pig influenza challenge model for evaluation of monoclonal antibody delivery platforms

A. McNee, T. Smith, B. Holzer, C. Becky, E. Bessell, G. Guibinga, H. Brown, K. Schultheis, P. Fisher, S. Ramos, A. Nunez, M. Bernard, V. Martini, T. Chrun, Y. Xiao, , E. Tchilian

This study establishes a pig influenza model to evaluate monoclonal antibody efficacy against H1N1, showing dose-dependent reduction in viral load and lung pathology.

bioRxiv · Mar 12, 2020Immunology