B. Kobe

Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products

This study investigates whether prokaryotic Thoeris TIRs can cross-activate plant TIR-immunity and finds they generate overlapping cADPR isomers but have distinct signaling requirements.

Chemical structures of cyclic ADP ribose (cADPR) isomers and the molecular basis of their production and signaling

The paper reports the chemical structures of two cADPR isomers, their production mechanism, and their roles in antiviral signaling and plant immunity suppression.

Self-association configures the NAD+-binding site of plant NLR TIR domains

This study identifies how self-association of TIR domains in plant NLRs configures the NAD+-binding site, linking it to NADase activity and signaling.

Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing

The paper determines the crystal structure of the Drosophila SARM1 ARM domain using MIRAS phasing, revealing insights into its regulation and activation mechanism.

The crystal structure of SnTox3 from the necrotrophic fungus Parastagonospora nodorum reveals a unique effector fold and insights into Kex2 protease processing of fungal effectors

The paper determines the crystal structure of SnTox3, a fungal effector, revealing a novel β-barrel fold and showing that it is a pre-pro-protein processed by Kex2 protease.