S. Hou

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

PI3K-dependant reprogramming of hexokinase isoforms controls glucose metabolism and functional responses of B lymphocytes

This study shows that PI3K-dependent upregulation of hexokinase 2 (HK2) controls glucose metabolism and immune functions in B cells, with HK2-deficient B cells showing impaired metabolic and functional responses.

Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

Deep learning-enhanced single-molecule spectrum imaging

This paper introduces SpecGAN, a deep learning method that significantly improves single-molecule spectrum imaging efficiency by reducing photon requirements and increasing temporal resolution.

Active-feedback 3D single-molecule tracking using a fast-responding galvo scanning mirror

This paper introduces a fast-responding galvo scanning mirror for RT-3D-SPT, improving tracking performance for single molecules and nanoparticles.

Mapping nanoscale forces and potentials in live cells with microsecond 3D single-particle tracking

This study introduces a high-resolution 3D single-particle tracking method to measure nanoscale forces and potentials in live cells using silver nanoparticles.

Transcriptomic analysis reveals hub genes and pathways in response to acetic acid stress in Kluyveromyces marxianus during high-temperature ethanol fermentation

This study identifies differentially expressed genes and pathways in Kluyveromyces marxianus under acetic acid stress during high-temperature ethanol fermentation, revealing effects on protein metabolism and ethanol production.

Type One Protein Phosphatase Regulates Fixed-Carbon Starvation-Induced Autophagy by Dephosphorylating ATG13a to Facilitate ATG1a-ATG13a Formation in Arabidopsis

This study shows that TOPP dephosphorylates ATG13a to promote autophagy in Arabidopsis by facilitating ATG1a-ATG13a complex formation during fixed-carbon starvation.

Estimating global variation in the maximum growth rates of eukaryotic microbes from cultures and metagenomes via codon usage patterns

The paper estimates maximum growth rates of eukaryotic microbes using codon usage patterns from genomes and metagenomes, revealing differences in growth potential between prokaryotic and eukaryotic communities in marine environments.

ARS2-directed alternative splicing mediates CD28 driven T cell glycolysis and effector function

This study shows ARS2 promotes CD28-driven T cell glycolysis and effector function through alternative splicing of Pkm2, enhancing anti-tumor immunity.

Estimating maximal microbial growth rates from cultures, metagenomes, and single cells via codon usage patterns

This paper develops a method to estimate microbial maximal growth rates using codon usage patterns and applies it to over 200,000 genomes, revealing biases in culture collections towards fast-growing organisms.

Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies

This study examines how somatic mutations in SARS-CoV-2 antibodies affect their neutralization potency, breadth, and resistance to escape mutations across six antibody lineages.

Immune elicitation by sensing the conserved signature from phytocytokines and microbes via the Arabidopsis MIK2 receptor

The paper identifies MIK2 as a plant receptor that recognizes conserved peptide motifs from phytocytokines and microbial proteins, triggering immune responses through a signaling relay.

Microbiota-root-shoot axis modulation by MYC2 favours Arabidopsis growth over defence under suboptimal light

This study shows that MYC2 modulates the microbiota-root-shoot axis in Arabidopsis, promoting growth over defence under low light by altering microbial communities and suppressing immune responses.

Ribosome-linked mRNA-rRNA chimeras reveal active novel virus-host associations.

The paper links marine viral gene expression to specific hosts using mRNA-rRNA chimeras, identifying novel virus-host associations and validating the method's accuracy.

Prime-boost vaccination of mice and Rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates

This study evaluates two adenovirus vectored COVID-19 vaccines in mice and macaques, showing strong immune responses after prime-boost vaccination.

IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity

This study identifies an IgA monoclonal antibody that blocks SARS-CoV-2 Spike-ACE2 interaction and provides mucosal immunity.

Precision engineering of the transcription factor Cre1 in Hypocrea jecorina (Trichoderma reesei) for efficient cellulase production in the presence of glucose

The paper modifies phosphorylation sites of the Cre1 transcription factor in Trichoderma reesei to enhance cellulase production under glucose repression.

Role of RgsA in oxidative stress resistance in Pseudomonas aeruginosa

This study shows that deletion of RgsA in Pseudomonas aeruginosa reduces growth and oxidative stress resistance in both planktonic and biofilm states.

Real-time 3D Single Molecule Tracking

This paper introduces 3D-SMART, a method for real-time 3D single-molecule tracking in solution, demonstrating its application to track DNA and RNA molecules with high temporal resolution.

GOT1 Inhibition Primes Pancreatic Cancer for Ferroptosis through the Autophagic Release of Labile Iron

This study shows that inhibiting GOT1 in pancreatic cancer primes cells for ferroptosis by promoting autophagy-mediated release of labile iron.

Molecular and structural mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir

This study determines the crystal structures of HCV NS3/4A protease from multiple genotypes bound to glecaprevir, revealing molecular mechanisms of pan-genotypic inhibition and resistance-associated substitutions.

Dscam homophilic specificity is generated by high order cis-multimers coupled with trans self-binding of variable Ig1 in Chelicerata

The paper shows that Dscam isoforms in Chelicerata form cis-multimers and trans-self-bind via Ig1 domains to generate unique homophilic recognition specificities for neuronal self-avoidance.

Glutamate-ammonia ligase promotes lung cancer cell growth through an enzyme independent upregulation of CaMK2G under a glutamine-sufficient condition

This study shows GLUL promotes lung cancer cell growth under glutamine sufficiency through enzyme-independent upregulation of CaMK2G.

Benchmarking metagenomic marine microbial growth prediction from codon usage bias and peak-to-trough ratios

This study benchmarks methods for predicting marine microbial growth rates using codon usage bias and peak-to-trough ratios from metagenomic data.

TREEasy: an automated workflow to infer gene trees, species trees, and phylogenetic networks from multilocus data

TREEasy automates gene tree, species tree, and phylogenetic network inference from multilocus data, improving efficiency and reducing manual effort in evolutionary analysis.

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

Membrane association of VAMP2 SNARE motif in cells and its regulation by different lipid phases of synaptic vesicle membrane

This study investigates how lipid phases in synaptic vesicle membranes regulate the structure and function of the VAMP2 SNARE motif using in-cell NMR and lipidomic profiling.

Effects of topical PaiTeLing in nude mice implanted with human condyloma acuminatum tissue infected with HPV 6, 31, and 81: comparison with imiquimod and interferon-α-2b

This study compares the effects of PaiTeLing, imiquimod, and interferon-α-2b on HPV-infected tissue in nude mice, finding enhanced immune responses with imiquimod and PaiTeLing.

Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition

The paper identifies isoform switching between mutant IDH1 and IDH2 as a mechanism of acquired resistance to IDH inhibitors in cancers.