K. Heesom

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2.

The study examines how disease-associated WDR34 mutations affect cilia assembly and function in a knockout cell model, revealing diverse phenotypic impacts.

Nutrient and salt depletion synergistically boosts glucose metabolism in individual bacteria

This study shows that nutrient and salt depletion in E. coli increases glucose accumulation rates at the translational and posttranslational levels, challenging the view that growth rate alone reflects metabolic status.

A general role for MIA3/TANGO1 in secretory pathway organization and function.

The paper shows that TANGO1L and TANGO1S are essential for secretory pathway structure and function, with loss of both causing major defects in secretion and ER-Golgi organization.

The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro

This study identifies Alectinib as an FDA-approved drug that inhibits SARS-CoV-2 nucleocapsid phosphorylation and viral replication in vitro by targeting host kinases.

Novel mechanisms of efflux-mediated levofloxacin resistance and reduced amikacin susceptibility in Stenotrophomonas maltophilia.

This study identifies novel efflux pump mechanisms and regulatory systems contributing to levofloxacin resistance and amikacin susceptibility reduction in Stenotrophomonas maltophilia.

Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site

A small membrane protein critical to both the offensive and defensive capabilities of Staphylococcus aureus.

This study identifies and characterizes MasA, a small membrane protein in S. aureus that disrupts toxin production and immune resistance when inactivated, impairing infection in multiple models.

Subtractive Interaction Proteomics Reveal a Network of Signaling Pathways Activated by an Oncogenic Transcription Factor in Acute Myeloid Leukemia

This study uses subtractive interaction proteomics to identify signaling pathways activated by the t(6;9)-DEK/CAN oncogene in AML, revealing potential therapeutic targets.

Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function

This study identifies distinct roles of dynein-2 intermediate chains WDR34 and WDR60 in cilia formation and function using knockout cell lines.