Author

C. J. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cancer Biology· 1 Immunology· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 6 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Assay:cryo-EM· 3 Research Focus:protein structure prediction· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2

Frequent Co-Authors

A. J. Zaug· 2 shared D. S. Wuttke· 2 shared T. R. Cech· 2 shared A. C. Uzozie· 1 shared A. E. McKay· 1 shared A. Larbi· 1 shared A. Lorentzian· 1 shared A. Singhal· 1 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

A. J. Zaug

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Small LEA proteins as an effective air-water interface protectant for fragile samples during cryo-EM grid plunge freezing

K. M. Abe, C. J. Lim

The paper shows small LEA proteins protect fragile samples from air-water interface damage during cryo-EM plunge freezing, improving structural determination of multisubunit complexes.

bioRxiv · Feb 6, 2024 · PreprintBiophysics

Structure of human CST-pol-α/primase bound to a telomeric overhang poised for initiation of telomere C-strand synthesis

Q. He, X. Lin, B. L. Chavez, B. L. Lusk, C. J. Lim

The paper reports the structure of the human telomere C-strand fill-in preinitiation complex, revealing how CST and pol-/primase coordinate DNA synthesis.

bioRxiv · Dec 16, 2021Biochemistry

CST does not evict elongating telomerase but prevents initiation by ssDNA binding

A. J. Zaug, C. J. Lim, C. L. Olson, M. T. Carilli, K. J. Goodrich, D. S. Wuttke, T. R. Cech

The paper investigates CST's role in telomerase inhibition and shows it does not terminate ongoing telomerase extension but prevents initiation through ssDNA binding.

Nucleic Acids Research · Oct 28, 2021Peer-reviewedBiochemistry

A Calcium/Palmitoylation Switch Interfaces the Signaling Networks of Stress Response and Transition to Flowering

H. J. Park, F. Gamez-Arjona, M. Lindahl, R. Aman, I. Villalta, R. Carranco, C. J. Lim, E. Garcia, R. A. Bressan, S. Y. Lee, C. Sanchez-Rodriguez, J. M. Pardo, W.-Y. Kim, F. J. Quintero, D.-J. Yun

The paper identifies a calcium/palmitoylation switch mechanism that regulates flowering time and stress adaptation in plants by controlling the nuclear localization of SOS3/CBL4.

bioRxiv · Aug 5, 2021 · PreprintPlant Biology

HIV-1 Vpu promotes phagocytosis of infected CD4+ T cells by macrophages through downregulation of CD47

L. Cong, S. M. Sugden, P. Leclair, C. J. Lim, T. N. Pham, E. A. Cohen

This study shows HIV-1 Vpu downregulates CD47 on infected CD4+ T cells, enhancing macrophage phagocytosis and enabling macrophage infection by T/F viruses.

bioRxiv · Mar 16, 2021Microbiology

Proliferative and quiescent human gastric cancer stem-like cells are associated with differential chemoresistance and patient mortality

K. S. Ang, H. K. Lee, M. Chevrier, M. Goh, J. Ling, V. Koh, X. Zhang, J. C. Tan, N. Lee, S. Erdal Irac, Z. M. Lim, J. Lum, A. Tay, C. Antoine Dutertre, C. Tang, , J. Chen

This study identifies two stem-like gastric cancer subpopulations with distinct chemoresistance and survival outcomes using scRNA-seq and organoid models.

bioRxiv · Oct 23, 2020 · PreprintImmunology

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

A. C. Uzozie, E. K. Ergin, N. Rolf, A. Lorentzian, S. S. Weng, L. Nierves, T. G. Smith, C. J. Lim, C. A. Maxwell, G. S. Reid, P. F. Lange

This study compares proteome and post-translational modification landscapes between pediatric leukemia patients and their xenograft models, finding both similarities and key divergences.

bioRxiv · Dec 18, 2019Cancer Biology

The cryo-EM structure of human CST reveals a two-megadalton decameric assembly bound to telomeric DNA

C. J. Lim, A. T. Barbour, A. J. Zaug, A. E. McKay, D. S. Wuttke, T. R. Cech

The paper reports the cryo-EM structure of human CST bound to telomeric DNA, revealing a decameric supercomplex and providing insights into CST function and disease associations.

bioRxiv · Oct 23, 2019Biophysics