Q. He

A receptor kinase complex refines cambium activity in Arabidopsis

This study identifies PXY-ER complexes as essential for cambium activity in Arabidopsis, showing that PXY signaling depends on ER signaling and explains ER function in the cambium.

Artesunate, EDTA and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

This study shows that artesunate, EDTA, and colistin work together to fight Salmonella strains resistant to colistin, by damaging cell membranes and inhibiting MCR-1.

The J-Like Protein ARC6 Regulates Chloroplast FtsZ-Ring Assembly through Fine-tuning ARC3 Activity in Arabidopsis

The paper identifies ARC6 as a regulator of chloroplast division by modulating ARC3 activity through its J-like domain, ensuring proper Z-ring assembly and positioning.

Structural basis for the concerted antiphage activity in the SIR2-HerA system

This study determines the cryo-EM structures of SIR2, HerA, and their complex, revealing their structural basis for antiphage activity and functional interactions.

Bio-inspired mineralization collagen induce fibrocartilage regeneration after tendon-bone injury by activating Gli1+Dkk3+ progenitor cells

This study develops a bio-inspired hydrogel that promotes tendon-bone interface regeneration by activating Gli1+Dkk3+ progenitor cells, achieving 68% mechanical recovery.

Stabilization of RRBP1 mRNA via an m6A-dependent manner in prostate cancer constitutes a therapeutic vulnerability amenable to small-peptide inhibition of METTL3

This study identifies METTL3-mediated stabilization of RRBP1 mRNA via m6A in prostate cancer and develops small-peptide inhibitors to target this pathway.

Alternating Polarity as a Novel Strategy for Cultivating Electro-Methanogenic Microbial Communities Capable of Robust Biogas Production

This paper develops an alternating polarity strategy to cultivate electro-methanogenic microbial communities, resulting in higher biogas production and structurally distinct communities.

A conserved and druggable pocket in class B G protein coupled receptors for orally active small molecule agonists

This study identifies a conserved binding pocket in class B GPCRs that enables small molecule agonists like PCO371 to activate G proteins without triggering arrestin signaling.

Long-term reliable neural decoding based on flexible implantable microelectronics and machine learning for seizure prediction application

This study combines flexible implantable microelectronics with machine learning to achieve reliable long-term neural decoding for seizure prediction in epileptic mice.

Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of anti-malarial drug resistance

This study develops a model showing that antigenic diversity influences biogeographic patterns of anti-malarial drug resistance, with resistance declining in high-diversity regions and persisting in low-diversity areas after drug discontinuation.

Novel inhibitors against COVID-19 main protease suppressed viral infection

This study identifies novel small-molecule inhibitors of SARS-CoV-2 main protease that suppress viral replication in human cells.

Structure of the human UBR5 E3 ubiquitin ligase

This paper determines the dimer and tetramer structures of human UBR5, revealing its oligomerization mechanism and functional implications for cancer.

PF-D-Trimer, a broadly protective SARS-CoV-2 subunit vaccine: immunogenicity and application

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.

Robust eIF4B levels undermine invasive growth and immune evasion mechanisms in murine triple negative breast cancer models.

This study shows that higher eIF4B levels in murine triple negative breast cancer models are linked to less aggressive tumor growth and better patient outcomes.

Dissecting the genetic basis of the heterosis of Y900, an elite super-hybrid rice

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

Neutral vs. non-neutral genetic footprints of Plasmodium falciparum multiclonal infections

This paper compares two methods for estimating malaria parasite multiplicity of infection under different transmission intensities, finding that varcoding is more robust in high-transmission settings while THE REAL McCOIL performs better in low-to-moderate transmission.

Structural basis of Yta7 ATPase-mediated nucleosome disassembly

This study reveals how Yta7 ATPase disassembles nucleosomes by unfolding histone H3 through a rotary staircase mechanism involving its BRD and AAA+ modules.

Structure of human CST-pol-α/primase bound to a telomeric overhang poised for initiation of telomere C-strand synthesis

The paper reports the structure of the human telomere C-strand fill-in preinitiation complex, revealing how CST and pol-/primase coordinate DNA synthesis.

High Resolution Nanostructure with Two-stages of Exponential Energy Dissipation at the Ultrathin Osteochondral Interface Tissue of Human Knee Joint

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

Amplification-free detection of viral RNA by super resolution imaging-based CRISPR/Cas13a System

This paper develops a CRISPR/Cas13a system combined with super resolution imaging for direct, amplification-free viral RNA detection with improved sensitivity.

Hexapeptide induces M2 macrophage polarization via the JAK1/STAT6 pathway to promote angiogenesis in bone repair

This study shows that the hexapeptide WKYMVm promotes M2 macrophage polarization via the JAK1/STAT6 pathway, enhancing angiogenesis in bone repair.

Somatic mutations of activated signaling genes, transcription factors, or tumor suppressors are a precondition for leukemic transformation from myelodysplastic syndromes: a sequencing analysis of 64 paired samples

Tetratricopeptide repeat domain 36 protects renal tubular cells from cisplatin-induced apoptosis via maintaining mitochondrial homeostasis

This study shows TTC36 protects renal tubular cells from cisplatin-induced apoptosis by maintaining mitochondrial homeostasis and autophagy.

Silencing of lncRNA NEAT1 inhibits esophageal squamous cell carcinoma proliferation, migration, and invasion via regulation of the miR-1299/MMP2 axis

This study shows that silencing lncRNA NEAT1 suppresses ESCC cell proliferation, migration, and invasion by regulating the miR-1299/MMP2 axis.

Frequency-dependent competition between strains imparts resilience to perturbations in a model of Plasmodium falciparum malaria transmission.

This paper shows that frequency-dependent selection increases resilience of malaria transmission systems to intervention compared to neutral processes.

The nucleotide messenger (p)ppGpp is a co-repressor of the purine synthesis transcription regulator PurR in Firmicutes

This study shows (p)ppGpp acts as a co-repressor of PurR in Firmicutes, downregulating purine synthesis by enhancing PurR DNA binding, with implications across environments from the gut to pathogens.

SARS-CoV-2 infection causes transient olfactory dysfunction in mice

This study shows SARS-CoV-2 infection causes temporary olfactory dysfunction in mice by targeting olfactory epithelium cells and disrupting their structure and function.

Collagen induced inflammations

This paper describes a protocol for inducing collagen-induced arthritis (CIA) in mice using bovine collagen type II and Freund's adjuvants, and reports associated enteritis and arthritis outcomes.

Frequency shapes the quality of tactile percepts evoked through electrical stimulation of the nerves

This study shows that increasing electrical stimulation frequency up to 50 Hz improves tactile perception quality, but beyond this point, perception stabilizes and discrimination ability declines.

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.